Exploring The Hormonal Route. Hair=life.

[Pls_NW-1]

I really dislike spironolactone because of its effect on many things like the electrolyte imbalance effect and many more, just no. Especially of the fact that you need to increase dosage after time to make it "still work"... Thats really a pain in the *** for people trying to fight hair loss for life. You can't take huge amounts of a SAA, like spironolactone, just no, don't do it if you appreciate your health.

 

[John Difool]

Orally only. It needs to be synthesized in your digestive system. All the spironolactone creams out there are snake oil.

 

[Pls_NW-1]

Thats why I would choose Bicalutamide. Tho I would consider taking Eplerenone or any other MCR agonist with Bicalutamide as it seems that the regrowth on spironolactone is superior to Bica, reason may be to the MCR properties spironolactone has. And Eplerenone has the MCR properties, but no AA properties.

 

[John Difool]

I really dislike spironolactone because of its effect on many things like the electrolyte imbalance effect and many more, just no. Especially of the fact that you need to increase dosage after time to make it "still work"... Thats really a pain in the *** for people trying to fight hair loss for life. You can't take huge amounts of a SAA, like spironolactone, just no, don't do it if you appreciate your health.

I am not aware of increase dosage for spironolactone under hrt. The dosages I have seen range from 100-200

 

[Norwoody]

Yeah if my current regimen doesn't get regrowth then I will definitely have to just get some kind of transplant. There is a cure, but it's all about how far you are willing to go.

 

[Pls_NW-1]

I am not aware of increase dosage for spironolactone under hrt. The dosages I have seen range from 100-200

Yes, thats the dose you need, especially for hair, however, users on this forum proved all the time again that they needed to increase their dosage.

 

[Norwoody]

Yes, thats the dose you need, especially for hair, however, users on this forum proved all the time again that they needed to increase their dosage.

Probably because of the steroidal pathway. It's hard to regulate long term use on ANY steroid

 

[John Difool]

The only AA that has demonstrated resistance in Daro

 

[Pls_NW-1]

The only AA that has demonstrated resistance in Daro

And it's used for resistant PC... haha, what a joke

 

[John Difool]

Yeah if my current regimen doesn't get regrowth then I will definitely have to just get some kind of transplant. There is a cure, but it's all about how far you are willing to go.

Cure my arse. You will still lose the rest of your follicles with the extent of your targeted norwood assigned to you at birth.

 

[Pls_NW-1]

Probably because of the steroidal pathway. It's hard to regulate long term use on ANY steroid

Probably, CB-03-01 is from the same class, no wonder it works soo poorly, and it's effects decrease just about 6 months. Pure BS lol

 

[John Difool]

And it's used for resistant PC... haha, what a joke

What's so funny about it? Do you think AA where invented for you to carry a hairstyle?

 

[Pls_NW-1]

Cure my arse. You will still lose the rest of your follicles with the extent of your targeted norwood assigned to you at birth.

I am doomed to be NW7 with severe donor thinning. I still have a NW2, but diffuse NW7.

And I am 17.

 

[John Difool]

the affinity of bicalutamide for the AR is relatively low as it is approximately 30 to 100 times lower than that of DHT, which is 2.5- to 10-fold as potent as an AR agonist as testosterone (https://en.wikipedia.org/wiki/Bicalutamide )
So even if dutasteride block the production of DHT from T, and even if bicalutamide is sitting on the androgen receptors, the frontdoor DHT and the backdoor DHT can easily kick out the bicalutamide, and then simulate the androgen receptor 2 to 10 times more than T.

 

[Pls_NW-1]

What's so funny about it? Do you think AA where invented for you to carry a hairstyle?

No, but the fact it was invented for resistant PC is just ridiculous imo.

 

[Norwoody]

Cure my arse. You will still lose the rest of your follicles with the extent of your targeted norwood assigned to you at birth.

Well there's AntyDHTor who went Norwood negative infinity xD

 

[John Difool]

Like I said. We are talking about 4% cases who will still experience hair loss after chemical or physical castration. Some folks are luckier than others. 96% of them.

 

[John Difool]

Well there's AntyDHTor who went Norwood negative infinity xD

I'd like to see a recent photo of him.

 

[Norwoody]

I'd like to see a recent photo of him.

Me too

 

[Swarleyd]

Why don’t you use spironolactone instead of bica as an AA? What are the cons ?