If Bicalutamide were weak against DHT, it would not lower PSA by 90%. The main hormone of the prostate gland is DHT.
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Trans masculinize all the time due to DHEA.. etc...
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Sure. Ever heard of resistant prostate cancer? Haha thats the reason why it is "resistant" against Bicalutamide. Other reason could be because it uses Bicalutamide as a co-activator and not corepressors, but this happens only in prostate cancer.
When the cancer is resistant, Abiraterone Acetate is used to shut down adrenal gland as well.
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Yes f***.... I am feeling desperate.
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You will be left without any sex hormones, it's worse than physical castration. Because not just the gonadal source is shut down, but the adrenal one as well, due to Abiraterone Acetate's effects.
when I saw how much abiraterone acetate costs, I fell off my chair.
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Yes a male form does exist! Instead of "ovarian pcos" it is "adrenal pcos" (about 10% of women have this rarer form of pcos too).Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist? - PMC
Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (Androgenetic Alopecia). It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine ...www.ncbi.nlm.nih.gov
An abnormal response to stress may be part of what drives it. Lowering stress with magnesium, ashwaghanda or other adaptogenic herbs, and vitamin B5 may be useful.
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I wonder how you can "cure" male adrenal pcos, I really think I got that F
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But if my Androstenedione would be high, then my T should be high as well!? Or would the higher T only be localized, eg. in the follicle!?
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Yes sorry, I think I spoke too soon. It's unlikely you will have abnormal androstenedione based on your current t levels.
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The only thing I could think of is, that the DHEA-S circulates to... and reaches peripheral tissues (skin), and gets converted THERE to potent androgens, such as DHT and T,... in a locilzed manner. That could explain as well why my T is in a barebone level, meanwhile I experience baldness...
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Yes! This is completely possible for dhea-s to convert to T in peripheral tissues rather than in serum.
Scroll down to the female androgenic hormone production chart and read below:
"DHEA/DHEA-S and androstenedione. These hormones can be converted to testosterone by peripheral tissues in the body."
Adrenal PCOS - How Stress Affects Your Hormones | Chris Kresser
Is stressing about your diet and exercise routine causing PCOS symptoms? Learn how to change your lifestyle and get your hormonal health back on track.
chriskresser.com
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I got excessive oxidative stress, hurting my (blood) cells.Yes! This is completely possible for dhea-s to convert to T in peripheral tissues rather than in serum.
Scroll down to the female androgenic hormone production chart and read below:
"DHEA/DHEA-S and androstenedione. These hormones can be converted to testosterone by peripheral tissues in the body."
Adrenal PCOS - How Stress Affects Your Hormones | Chris Kresser
Is stressing about your diet and exercise routine causing PCOS symptoms? Learn how to change your lifestyle and get your hormonal health back on track.chriskresser.com
I also have a laboratory up-close picture of them, might share them later. They look like they´re dying lol
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I just started experiencing some worrying side effects of oral minoxidil.
Namely swelling in my ankles/feet, as well as a persistent feeling of nausea.
And, I think, an increase in heart rate.
Fortunately, the swelling has gone down, but the nausea remains as well as the (possible) heart rate increase.
These side effects really make me worried about HRT meds, namely AA and their far more serious side effects.
Namely swelling in my ankles/feet, as well as a persistent feeling of nausea.
And, I think, an increase in heart rate.
Fortunately, the swelling has gone down, but the nausea remains as well as the (possible) heart rate increase.
These side effects really make me worried about HRT meds, namely AA and their far more serious side effects.
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I've been taking it for a little less than two weeks.better get a better educated doctor
Salt and water retention: Minoxidil can cause salt and water retention. This can lead to congestive heart failure. To avoid this, your doctor should prescribe a diuretic (water pill) for you to take with minoxidil.
Is that enough time to cause serious or permanent damage?
Doesn't bicalutamide block androgens produced locally via DHEA? Bica occupies a receptor, what's the difference where the hormone came from if the receptor is busy
It is also used in women to treat PCOS, treat hirsutism
@Ticken
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