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I am also thinking that adding spironolactone might help with some or all of the hypertrichosis.
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Do spironolactone receptors and estrogen receptors overlap? I am just wondering why estradiol together with spironolactone would be useful. I have a feeling that spironolactone and estradiol are synergistic. I am starting back to 50mg daily to see if it makes my beard less scratchy which annoys me to no end since I added oral minoxidil. I probably should have just reduced my dosage of spironolactone but I shall see if there are any sides from using only 50mg and to see if there's synergy.
ive been taking 50mg and 1mg estradiol + .75mg estrogel for 2.5 months and no bad sides yet and am seeing minor growth on the hairline. Im really looking to increase overall density but that looks like it could be achieved at the 6-8month mark
I heard that people were losing ground trying to maintain the result obtained by Spironolactone with Bicalutamide
spironolactone has an estrogen-like effect. It may not be possible to maintain estrogen results with Bica, especially hair quality and texture
In a mouse study, we see that Bicalutamide does not completely prevent the effects of DHT, which I can see from the fact that I still have a small amount of acne and sebum. Possibly needed dosages of 150mg, which are comparable to castration
Ikarus also complained about his hairline, although he uses Estrogen with Bicalutamide. So everything may not be as easy as it seems at first glance ...
In general, this is all theory. I intend to test everything in practice
spironolactone has an estrogen-like effect. It may not be possible to maintain estrogen results with Bica, especially hair quality and texture
In a mouse study, we see that Bicalutamide does not completely prevent the effects of DHT, which I can see from the fact that I still have a small amount of acne and sebum. Possibly needed dosages of 150mg, which are comparable to castration
Ikarus also complained about his hairline, although he uses Estrogen with Bicalutamide. So everything may not be as easy as it seems at first glance ...
In general, this is all theory. I intend to test everything in practice
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It's funny. I took one on one day and I became ravenously hungry for NaCl.
Ikarus also started 5mg oral minoxidil because he wasn't 100% happy with his results from bica and estradiol alone and had really great results, estradiol and minoxidil seem to work great together, whether oral or topical.
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Unfortunately, only HRT will help you. Bicalutamide will only stop baldness, but you need to grow your hair. You can start right away with 50mg Bicalutamide + 2-4mg E, and then try to support the result with 75-100mg Bicalutamide. You will also have to undergo surgery to remove gynecomastia.
Bicalutamide only stops and slightly improves hair quality and thickness, just like castration. Estradiol is responsible for any re-growth, without it it will not be possible to return the hair. I want to try Estradiol, but give it up and try to keep the result on Bicalutamide
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I sadly don't have access to bicalutamide and HRT. Maybe Bicalutamide in a few months, but for HRT, I would need to start a job and that would be pretty hard in my current position.
Life is so unfair.
Any thoughts on using cyclodextrins as a topical E2 delivery mechanism to avoid systemic effects?
www.ncbi.nlm.nih.gov
Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery - PMC
www.ncbi.nlm.nih.gov
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The cheapest option for e2 is lena's injectable. If feminizing sides aren't a concern for you, then monotherapy could be an option. It depends on the dosage, but around £100 will get you a years supply.I sadly don't have access to bicalutamide and HRT. Maybe Bicalutamide in a few months, but for HRT, I would need to start a job and that would be pretty hard in my current position.
Life is so unfair.
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Your temples are still very good. Honestly better than mine after a full year of treatment. I wouldn't worry about your temples. The top of your head is worse, but I've always heard anecdotally that that area is easier to regrow than temples.
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spironolactone is no longer in vogue any more among trans women partly because it seems like it might stunt breast growth, though this might be a positive effect for many people on here
Its effects mineralocorticoid receptors also seems to have benefits for hair growth
Still, I would personally avoid it due to its side effect profile.
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spironolactone is only popular because it's cheap... and breast growth getting stunted by spironolactone is also known as pointy nipples syndrome. You dont want that, trust me. You'd prefer regular gyno.
ClinicalKey
www.clinicalkey.com
Also look at the research showing that prostate cancer survival is better when a 5AR blocker is added to Bicalutamide. Well, just logic: less DHT - less competition for receptors
finasteride / Duta have a supporting role, the main work is performed by Bicalutamide. 5Ar blocker - a little help that, in theory, could allow for slightly lower doses of Bicalutamide