Finasteride cause DNA damage . new study in vivo

[JohnSmith21]

Correct on this point, multiple environmental factors both positive and negative can change your DNA.

This is like what you said above, there are obese people who take finasteride for example. Obesity itself causes ED and a low sex drive. My point is, there are other factors in people’s lives other then finasteride. I’ve gone through periods before finasteride when my sex drive was lower, and If I was on finasteride at the time, I would have probably attributed it to that. Since I’ve been on it though my sex drive has been great haha

 

[Geezer]

yes, you nuked one of the hormones that make you think, act, look and feel like a male by 70%. which is why it's prescribed to trannies
If it works out for you, that's great. If you think it will work out for your kid, that's also great. Heck, it might!

No offence I would suggest you let Pigeon give the Cons on finasteride, he at least does it in a far more intellectual way.

 

[JohnSmith21]

yes, you nuked one of the hormones that make you think, act, look and feel like a male by 70%. which is why it's prescribed to trannies
If it works out for you, that's great. If you think it will work out for your kid, that's also great. Heck, it might!

I mean I’m sure a tranny would take it to ..... not lose hair? But it isn’t taken by them to feminize them lmao. I don’t feel or look any different since been on finasteride and I have more hair then I used to. I’m still fit, I still have a thick beard, and I still have a lot of chest hair. Nothing you are saying has applied to me. And nothing you are saying applies to MOST people who take the drug. That is my main point here. And you and pigeon sound like your COPING with your choice to not take it! I have no regrets and nothing to justify lol

 

[JohnSmith21]

No offence I would suggest you let Pigeon give the Cons on finasteride, he at least does it in a far more intellectual way.

Yeah pigeon makes okay points at least, this other dude actually just says whatever make believe nonsense pops into his head. Pigeon, it’s people like this^ guy who actually hurt your argument

 

[Geezer]

This is like what you said above, there are obese people who take finasteride for example. Obesity itself causes ED and a low sex drive. My point is, there are other factors in people’s lives other then finasteride. I’ve gone through periods before finasteride when my sex drive was lower, and If I was on finasteride at the time, I would have probably attributed it to that. Since I’ve been on it though my sex drive has been great haha

Yes but, my point isn’t to state of if I’m healthy basically finasteride is completely good. No, again it’s optimal for hair and prostate that’s it. The emphasis on health is just somthing I feel is far more important especially when in finasteride, specifically because it’s not “healthy” in inhibiting DHT/5AR, your compensating in a sense.

 

[czecha]

Yeah pigeon makes okay points at least, this other dude actually just says whatever make believe nonsense pops into his head. Pigeon, it’s people like this^ guy who actually hurt your argument

Sure, bringing up the point that you cannot rule out that your future child will be affected by your finasteride usage hurt his argument. Close the thread already

 

[JohnSmith21]

Yes but, my point isn’t to state of if I’m healthy basically finasteride is completely good. No, again it’s optimal for hair and prostate that’s it. The emphasis on health is just somthing I feel is far more important especially when in finasteride, specifically because it’s not “healthy” in inhibiting DHT/5AR, your compensating in a sense.

I am literally saying that most people won’t notice any sides or negative impacts to their health, and that if they by some chance do, it will go away when they stop taking it. That’s all I’m saying. I don’t think anyone should be anti-finasteride the way some of these people are. But no I don’t think it’s like taking candy, and I personally will stop or lower the dose if I get sides *knock on wood*

 

[JohnSmith21]

Sure, bringing up the point that you cannot rule out that your future child will be affected by your finasteride usage hurt his argument. Close the thread already

Because there isn’t proof of that lmao. That’s like me saying your future child is going to be retarded because your underwear is too tight and because you keep your phone in your pocket

 

[czecha]

I am literally saying that most people won’t notice any sides or negative impacts to their health, and that if they by some chance do, it will go away when they stop taking it. That’s all I’m saying. I don’t think anyone should be anti-finasteride the way some of these people are. But no I don’t think it’s like taking candy, and I personally will stop or lower the dose if I get sides *knock on wood*

even your heros at merck had to admit PFS is a thing, so how in the f*** are you making statements like this?

 

[JohnSmith21]

Sure, bringing up the point that you cannot rule out that your future child will be affected by your finasteride usage hurt his argument. Close the thread already

This guy is literally no different then a “flat earther” in terms of how he approaches things lol

 

[czecha]

Because there isn’t proof of that lmao. That’s like me saying your future child is going to be retarded because your underwear is too tight and because you keep your phone in your pocket

time to head out of here I thought you were just coping and not literally retarded

 

[JohnSmith21]

time to head out of here I thought you were just coping and not literally retarded

You saying what your saying is the same is that. You have no proof of anything you’ve said. I literally am citing studies and trials that have been consistent over the past 25 years. You are literally just saying things with no facts or proof to back it up, the same way flat earthers do lol. You have no argument you are just an ocd hypochondriac with an opinion, and sadly, that doesn’t count for anything

 

[Geezer]

This proves again you know nothing. (no wonder you believe fina is safe)

Do you even know about how many people have success with minoxidil/needling combo? Check out the big thread.

About topical duta, there is a theory why it causes les sides and a couple of users here confirm that theory, they had sides on oral fina and even topical fina but not on topical duta. ( https://fuehairdoctor.co.uk/topical-dutasteride-dr-lupanzula/ )

If you still take oral fina/duta anno 2020 you really know nothing or don't care about your health imo.

Very true, people do underestimate the effectiveness of minoxidil mixed with retin a (increasing minoxidil sulfate and proliferation), microneedling (increasing growth factors, minoxidil sulfate on scalp, and allowing minoxidil to penetrate the scalp). Especially if your hair loss is not extremely aggressive it can keep you above baseline for years.

All research I’ve seen on topical finasteride seems to indicate it goes systemic to a great degree even with different solutions due to its Dalton weight. It may be useful for people microdosing finasteride, in theory if you use topical minoxidil vs oral or applying test creams to certain areas, you can have more scalp DHT being inhibited at small doses topical, compared to orally.

Topical Dutasteride seems very interesting and if more research comes along, even if it demonstrates a mild DHT inhibition, 5-20%, I will definitely hope on it.

Zix, guess this is the point were I have to disagree. If we are gonna have a discussion based on reason and science I cannot see why this can be pushed, with merely anecdotal data and in vitro studies. Cause if that is our holy grail then azalic acid, B6, zinc would be the holy grail inhibiting 90+% DHT. However to be honest not even a big things to fuse over and honestly I would rather much people use ZIX then waste there money on that bullshit Alfatradiol, 0.025, 40 times less in quantity then they used in the Cosmo study.

All in all we agree in the majority of the points you made earlier though, even on finasteride and DHT. Expect that stuff I read on that other thread, you gotta calm down with that wicked sh*t, it may be the internet but, just let it slide writing that stuff can’t be good for the soul. Anyways information I see you post although may trigger many, gives people a broader perspective on finasteride. I’m all in for safer AND effective hair loss option that can come in the future. People often make the excuse that new options will not come but, scientific inovation and understanding of hair loss is going up exponentially, anyone with two brain cell can see that. Glad your protocol has gotten you good results though, have a good day

 

[Geezer]

Fair enough
Also not saying it does cause DNA damage, just saying idk if it does and that I doubt any1 has a full enough picture of everything to rule it out. Which is enough for me to make a decision
So just sharing my though process

To be honest what you just said is a perfectly sound reason not to use finasteride, especially since it is a personal choice. The fear and understanding of not knowing “exactly” what It can do is perfectly logical. No need to explain why you don’t take finasteride it’s no ones business and like my previous post demonstrated, pressure or ridiculing people for not using finasteride is f*****g idiotic.

you definitely should have said this from the start instead of the tranny stuff. This was a good response

 

[DogoDiLaurentiis]

they say this is the mechanism of hair loss in men and women
View attachment 151488
Why doesn't taking exogenous progesterone solve the problem then

Becaaauuuuse... progesterone lowers estrogen. Too much progesterone and that hormone that is responsible for initiating and sustaining hair growth plummets.

I know I sound like a broken f*****g record and just ignore me if you don't want to hear it, but yes "technically" progesterone interferes with DHT, but we're now getting collectively to a point where it's becoming increasingly obvious why certain hairloss drugs that interfere with hormones actually work, and it's because estrogen is the driver of hair growth, it sustains hair.

Even if you don't believe in actually taking estrogen understand that men still have levels of estrogen in their bodies and it's significant even under healthy conditions.

I've used progesterone topically even pharmaceutical grade oral progesterone in order to interfere with androgenic hair loss, it did not work for me, and I'm starting to understand why now. The same applies with why finasteride did not work for me out of the gate and simply did not get me anywhere. My body was not converting testosterone to estrogen the way it once was.

There's a reason why some men have absolutely apocalyptic levels of hair loss on progestin based steroids such as Trenbolone. It acts as a progesterone agonist and does not potentiate aromatase and so basically your estrogen levels go bye bye.

 

[Geezer]

Becaaauuuuse... progesterone lowers estrogen. Too much progesterone and that hormone that is responsible for initiating and sustaining hair growth plummets.

I know I sound like a broken f*****g record and just ignore me if you don't want to hear it, but yes "technically" progesterone interferes with DHT, but we're now getting collectively to a point where it's becoming increasingly obvious why certain hairloss drugs that interfere with hormones actually work, and it's because estrogen is the driver of hair growth, it sustains hair.

Even if you don't believe in actually taking estrogen understand that men still have levels of estrogen in their bodies and it's significant even under healthy conditions.

I've used progesterone topically even pharmaceutical grade oral progesterone in order to interfere with androgenic hair loss, it did not work for me, and I'm starting to understand why now. The same applies with why finasteride did not work for me out of the gate and simply did not get me anywhere. My body was not converting testosterone to estrogen the way it once was.

 

[-G-]

Again though. A poll here is garbage. You are taking a poll of people on a forum due to sides, and are surprised that people said they have sides? A poll of the general population taking finasteride would be closer to 2%. I guess agree to disagree lol

This is an important note, polling here in this venue would not be a true reflection of what others feel/experience.

I am on finasteride and often wonder things...just trying to get married and have children that aren't mine - according to some people haha.

 

[czecha]

Becaaauuuuse... progesterone lowers estrogen. Too much progesterone and that hormone that is responsible for initiating and sustaining hair growth plummets.

I know I sound like a broken f*****g record and just ignore me if you don't want to hear it, but yes "technically" progesterone interferes with DHT, but we're now getting collectively to a point where it's becoming increasingly obvious why certain hairloss drugs that interfere with hormones actually work, and it's because estrogen is the driver of hair growth, it sustains hair.

Even if you don't believe in actually taking estrogen understand that men still have levels of estrogen in their bodies and it's significant even under healthy conditions.

I've used progesterone topically even pharmaceutical grade oral progesterone in order to interfere with androgenic hair loss, it did not work for me, and I'm starting to understand why now. The same applies with why finasteride did not work for me out of the gate and simply did not get me anywhere. My body was not converting testosterone to estrogen the way it once was.

There's a reason why some men have absolutely apocalyptic levels of hair loss on progestin based steroids such as Trenbolone. It acts as a progesterone agonist and does not potentiate aromatase and so basically your estrogen levels go bye bye.

that would certainly explain why the only time i ever regrew hair, my nipples were sensitive as f*** and gyno was coming

is there such a thing as raising E only in the scalp?

 

[DogoDiLaurentiis]

That is 100% why I am going to apply it topically, my currently un-ideal hormonal state in which my testosterone is high and I am not converting it into estrogen much seems to be the perfect opportunity to apply it in a balanced concentration topically and evaluate both how quickly and how much it affects me systemically.

My hair has recovered in the past to an extremely thick state without inducing the symptoms you're describing or a runaway excess of fat accumuation. So I know my body has enough of a tolerance for estrogen that I can probably replicate it again with a topical.

The advantage of course being that when your body is converting it internally, you have more of an uphill battle controlling aromatase to an ideal level. In the case of applying it to your scalp first, you get the direct benefits of estrogen acting on the follicles and skin receptors of the scalp. After which it takes time to absorb into the body and have a systemic effect and that's the key, you do have a chance to balance it out once it gets there.

That and that the absorption rate won't be perfect, so you have that working for you as well.

 

[czecha]

That is 100% why I am going to apply it topically, my currently un-ideal hormonal state in which my testosterone is high and I am not converting it into estrogen much seems to be the perfect opportunity to apply it in a balanced concentration topically and evaluate both how quickly and how much it affects me systemically.

My hair has recovered in the past to an extremely thick state without inducing the symptoms you're describing or a runaway excess of fat accumuation. So I know my body has enough of a tolerance for estrogen that I can probably replicate it again with a topical.

The advantage of course being that when your body is converting it internally, you have more of an uphill battle controlling aromatase to an ideal level. In the case of applying it to your scalp first, you get the direct benefits of estrogen acting on the follicles and skin receptors of the scalp. After which it takes time to absorb into the body and have a systemic effect and that's the key, you do have a chance to balance it out once it gets there.

That and that the absorption rate won't be perfect, so you have that working for you as well.

so are you thinking topical E combined with an ai inhibitor some time later? shouldn't that theoretically work without making you a woman