Agree with your tellings. I believe that because of the E3, E2 went down, as you mentioned, plus I think it happened a bit of both. Now, regarding this part:
"Now, if you increased the dosing, who knows, but since E3 is weaker than E2, I could see the body responding by increasing E2, possibly decreasing endogenous E3, if the dose is high enough".
How to get to the balance or into an equilibrium point? I mean having both because we need the E3 as well, not only the E2. Maybe the dosage from Bi-Estro (1 mg E3+0.25 mg E2) it's great for that? Either higher E3 dosage needed alone (makes sense) or something like Bi-Estro, especially for the low doses of E3 (1 mg). I don't know if the low dosage could do more harm than good this is why I am mentioning if E2 needs to be there as well (just a hypothesis and mention it because of the previous responses above). Thank you very much for responding.
**** https://www.hairlosstalk.com/interact/threads/trying-emu-oil-monoxidil-dmso-estriol-blend.126410/
Here is a great thread. The member was using
only 4mg Topical Estriol plus Minoxidil,
then changed to only E3+DMSO+Emu Oil (the topical solution), and the results are/were impressive! (Probably, the DMSO here plays a huge role in the absorption of Estriol in comparison to Ethanol+PPG, especially for topical solutions. (Also, I read on some other threads that the Ethanol+PPG mixture is better for absorption than the Cream). So, I believe that all the 4mg of Estriol fully utilized by dissolving it in DMSO).