- Reaction score
- 69
1000mg/10days = 100mg
Hair Today Hair Tomorrow Hair Forever
- Thread starter pegasus2
- Start date
ahhh I missed that part, thanks. I was like, here I am worried to start 20mg/day of RU and this guys doing 1000.
- Reaction score
- 69
Actually there was a user on discord who used 700mg of RU per day, along with flutamide lol
Is "was" the key word? Did he up and disappear one day?
- Reaction score
- 69
No don't worry
he stopped RU and flut because another user warned him about side effectsWhat side effects? I'm wondering if I should add it as we speak lolNo don't worry
- Reaction score
- 69
700mg of RU is too much and flutamide is hepatoxic. Personally I use RU 50mg/day, no sides.
How confident are you personally in the lack of long term sides? I'm only going to use a low dosage (20mg) but I'm still hesitant due to the unknown factor. finasteride I have had no problems with.
- Reaction score
- 69
Good question. It's a risk-benefit issue. I'll replace it when possible with an FDA approved AR antagonist, but I doubt it will be CB.
I feel like it's my last ditch effort to save presentable hair, so that's the benefit lol. If not CB, then what else is there?
I am in the same boat right now
- Reaction score
- 69
Oh-flut but is more expensive than RU.
Maybe in the future pyrilutamide.
I have a friend who thickened his hair with 2% atraric acid
As in off label Eucapil? Higher concentration?
- Reaction score
- 69
You mean Atraric Acid?
Oh-Flut?
Are you testing every batch?
There are always impurities, some are dangerous and some aren't. It's prohibitively expensive to test what the impurities are in every batch.
HI pegasus2,
I'm thinking about adding SAG to my protocol for a diffuse thinning Androgenetic Alopecia, but my point is about dosage, schedule and, in turn, cost, efficacy, safety.
How did you come to the dosage for SAG of 0.15%, 2 ml per day? Is it coming from your contacts that used it in the past?
In the study on mouse model, they used a really low concentration of 0.6 microg/microL and 25 microL solution in acetone 95% and DMSO 5%, even at single dose ,on an area the looks like 3-5 cm2. Induction ramped up for 5 days and lasted at least further 5 days. The authors commented they think there was a sort of lag for Shh induction due cell activation; SAG didn't go systemic.The same study run a test on excised fetal skin, daily application, % increased up to 0.15 microg/microL, but 8 microL and unknown air exposed area, nor the dosing rationale has been argumented.
But you have reported SAG EC/I50 curve, also with cyclopamine as inhibitor,showing a gauss-like behaviour, with inhibition of the activation at microM concentrations. As speculation for dosage, I have googled for mouse skin thickness and found something like 0.5 mm vs the 2.5-3.5 mm of human scalp skin, so factor 5-6X.
This is my math as backcalculation of the dosage of 0.15%, 2 ml.
They used approx 5 microL/cm2 ,15 microg total dose, so 3 microg/cm2
By assuming factor 5.5 because of human skin thickness, 150 cm2 application area, the dose would be 3X5.5X150=2475 microg, so 2.5 mg or 2 ml at 0.125%.
What is the reason for using it more than once in a 2 weeks Follica-like protocol?
I'm thinking about adding SAG to my protocol for a diffuse thinning Androgenetic Alopecia, but my point is about dosage, schedule and, in turn, cost, efficacy, safety.
How did you come to the dosage for SAG of 0.15%, 2 ml per day? Is it coming from your contacts that used it in the past?
In the study on mouse model, they used a really low concentration of 0.6 microg/microL and 25 microL solution in acetone 95% and DMSO 5%, even at single dose ,on an area the looks like 3-5 cm2. Induction ramped up for 5 days and lasted at least further 5 days. The authors commented they think there was a sort of lag for Shh induction due cell activation; SAG didn't go systemic.The same study run a test on excised fetal skin, daily application, % increased up to 0.15 microg/microL, but 8 microL and unknown air exposed area, nor the dosing rationale has been argumented.
But you have reported SAG EC/I50 curve, also with cyclopamine as inhibitor,showing a gauss-like behaviour, with inhibition of the activation at microM concentrations. As speculation for dosage, I have googled for mouse skin thickness and found something like 0.5 mm vs the 2.5-3.5 mm of human scalp skin, so factor 5-6X.
This is my math as backcalculation of the dosage of 0.15%, 2 ml.
They used approx 5 microL/cm2 ,15 microg total dose, so 3 microg/cm2
By assuming factor 5.5 because of human skin thickness, 150 cm2 application area, the dose would be 3X5.5X150=2475 microg, so 2.5 mg or 2 ml at 0.125%.
What is the reason for using it more than once in a 2 weeks Follica-like protocol?
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