Kythera Acquires Rights to PGD2 Inhibitor

[BiqqieSmalls]

You know who else I think knows something and is keeping quiet? Actelon (or whatever) the company that previously owned SET. They were testing it for asthma, and gave up on it because it was not strong enough, but I'm sure that they would have maybe noticed something in the hair department if it was working right?

There could be a million reasons why they gave up on Setipiprant. Perhaps they'd make much more money off the sale of the rights of Set instead of going through years of the FDA process and could then use that capital towards other therapies. There WILL be something coming. Look at all the competition there is. This is an unsaturated market with billions to be made. If you don't think another significant treatment or cure will come relatively soon, I advise you to read about economics.

 

[Dikek]

Years of fda process? According to kythera they will skip 90% of fda phase cus is alredy tested, maybe they underrate seti or their original plan was only ashma market while cotsarellis has the magical nobel scalp target vehicle and they didn't know. Or seti is useless and never showed hairgrow in their test but that's somethign i don't want to think.

Anyway what we can possible try similar to seti just as test? diclo and cetririzine? I don't want to wait months and months or years of silence while we are dying right now... i want something before the summer at least

 

[BiqqieSmalls]

i want something before the summer at least

Look at Follicept. Interesting product. Haven't seen trials for it though. The company suggested a Fall 2015 launch.

 

[Dikek]

I don't think follicept will be game changing, basically is developt by a couple of guys who use folli money to fund another product, and as funding source they use indiegogo..... come on.....

http://www.pennmedicine.org/providers/profile/george-cotsarelis

"request appointment" so you can actually get costarellis visit you? I don't know how much it cost but i think we can fund few hundread to get an appointment and meanwhile ask about setipriprant, how the things are going, trial ecc ecc someone who live in near philadelphia?
We need to stay active and move our ***, i don't want this thread dead for 1 or 2 years to the next seti news

 

[kirk]

Kythera stock has dropped just a bit. I doubt it means anything just wanted to bump the topic. Anybody heard anything?

 

[Fena2000]

Dumb question, what causes too much pgd2?

 

[BiqqieSmalls]

Kythera stock has dropped just a bit. I doubt it means anything just wanted to bump the topic. Anybody heard anything?

View attachment 31710

Buy low sell high? Doubt it has any correlation with Setipiprant

 

[benjt]

Dumb question, what causes too much pgd2?

The missing link between DHT and PGD2
This is the one mechanism that is still mostly not understood at all in Androgenetic Alopecia/male pattern baldness, the "missing link". It seems that some properties of the DSC cells determine whether the follicle will produce PGD2 when DHT is around, and it seems that the Dkk1 gene is involved. Unfortunately, not much more is known as to why there is too much PGD2 around - if we knew the exact mechanism behind DHT leading to too much PGD2 locally, we would be one huge step closer to a cure. But as we don't know the mechanism, we don't know what to address.

 

[bushbush]

Dumb question, what causes too much pgd2?

Not a dumb question.

The answer is possibly mast cell de-granulation. The following paper finds evidence of a PGD2 gradient (in the familiar 'horseshoe' pattern) in mast cells:

Larson, Allison R., et al. "A prostaglandin D-synthase-positive mastcell gradient characterizes scalp patterning." Journal of cutaneous pathology 41.4 (2014): 364-369.

This de-granulation may be regulated by mast cell androgen receptors:

Mayo,Juan C., et al. "Androgen-dependent mast cell degranulation in the Harderian gland of female Syrian hamsters: in vivo and organ culture evidence." Anatomy and embryology 196.2 (191997):133-140.

PGD2 (in general) is also a testosterone-responsive transcript, that is, the synthesis of the protein is influenced by testosterone:

N. S. Treister, S. M. Richards, T. Suzuki, R. V. Jensen, D. A. Sullivan, Influence of androgens on gene expression in the BALB/cmouse submandibular gland. J. Dent. Res. 84,1187–1192 (2005).

 

[Dikek]

Can someone get an appointment with cotsarellis so we can have some more info a breath again? What's the plan we are doing nothing and in two years we are pretty much DEAD

 

[KiNGTyreZe]

Can someone get an appointment with cotsarellis so we can have some more info a breath again? What's the plan we are doing nothing and in two years we are pretty much DEAD

Two years is too long. We need the sh#t now.

 

[kirk]

Two years is too long. We need the sh#t now.

Agreed. I'm waiting for Kane to contact with the update that he mentioned, but to be fair it's only been a few days since the 27th. I am unable to travel to PA to meet with Dr. Cots at the moment. If anyone is in a better position to do so, it can be arranged with this link. http://www.pennmedicine.org/providers/profile/george-cotsarelis

Also, anyone care to speculate on the secrecy surrounding this medication? If it is the golden cure, and they have sole rights to it, why not announce it?

 

[bushbush]

Can someone get an appointment with cotsarellis so we can have some more info a breath again? What's the plan we are doing nothing and in two years we are pretty much DEAD

Do you really think he is going to offer more information than is already published to some random guy 'from the internet'?

 

[hellouser]

Do you really think he is going to offer more information than is already published to some random guy 'from the internet'?

Do you really think that even if he got an appointment with him, he'd care to tell him anything more than what we already know?

- - - Updated - - -

Two years is too long. We need the sh#t now.

We needed it yesterday.

 

[Dikek]

I'd like to know just one thing, is the kane or another one setit the same product that we hopefully have in a couple of years? Can this setit (or oc) be useless because it doesn't target the right pathway? If their seti is different cuz we don't have the missing ingredient we are doomed to suffer till the end, and it's not a money related thing anymore

 

[foreverexile]

Any good news for us Asian bald brothers ?

 

[Armando Jose]

Dumb question, what causes too much pgd2?

I bet for rancid sebum .....

 

[bushbush]

I bet for rancid sebum .....

Based on what evidence?

 

[Fena2000]

Just found this patent, interesting, increased levels of pgd2 are also connected to acne and rosacea. I have rosacea, at least I think, derms haven't figured it out yet. I'm so sure if there was a pill I could take that antagonizes the pgd2 receptor, I would be cured of both rosacea and hairloss. http://www.freshpatents.com/-dt20110127ptan20110021599.php

 

[BiqqieSmalls]

Just found this patent, interesting, increased levels of pgd2 are also connected to acne and rosacea. I have rosacea, at least I think, derms haven't figured it out yet. I'm so sure if there was a pill I could take that antagonizes the pgd2 receptor, I would be cured of both rosacea and hairloss. http://www.freshpatents.com/-dt20110127ptan20110021599.php

The man, the myth, the legend; George Cotsarelis