DesperateOne
Banned
- Reaction score
- 18
Great post and welcome to the forums, yeah it sucks having your first couple of post backcatalogged and later reposted in a random order, but hopefully the admin removes the restrictions from your account soon. In any case: I fully agree with your point #2, most people here are extensively butchering into the dermis and not giving enough time for even new follicle formation to occur, but that is my opinion, I don't wanna get into a yelling session here again. On point #1 I disagree, blocking the EGF receptor isn't the only way. In you original patent link, follica has many methods described and blocking the EGFR is actually the most difficult and dangerous to achieve. Let's look at the patent you linked to:
Noticed the words I bolded, the EGF receptor inhibitor was administered as a single injection, timed perfectly and it helped induce more hair neo-genesis. Also notice the red lines? Anti androgens can actually achieve the same thing, given they are timed later in the stages of healing. I have actually suggested people here not use any anti androgens or anything for that matter except minoxdil in the early days of wound healing at all, because of unknown factors. This is why I don't want people to even think about applying an epidermal growth factor injector weekly (or more, as I suspect some people have a tendency to go overboard). The reason is simply because EGF is critical of anagen initiation of existing hair follicles. Take a look at this study:
http://www.ncbi.nlm.nih.gov/pubmed/12714603
So basically they are saying that EGF is necessary for initiating anagen for exiting hair already in telogen. On the other hand, follica has shown that that blocking the EGFR receptor is one way of creating "more" new hair. So if you dermaroll weekly and continue to block the EGFR, what will happen, you might induce some WIHN, but what about existing hair in telogen, they are literally fuc*ked, this is the reason why in the follica experiment it is perfectly timed and applied only once at a critical moment. My humble opinion? don't mess with EGFR. There are many other ways to induce WIHN as is given in the same patent you provided TNTS. Here are other examples they mention in the same patent:
Another example is simply minoxidil that is given in the same patent (which I advise everyone to simply stick to and not try the fancy stuff):
and so on and so on, so essentially follicular neo-genesis can be triggered by many factors, heck, even introducing nothing can create brand new follicles creation, flamethrower provided. Something I also want to take from the patent you provided is this: wound healing creates a very strange environment where substances can cause un-intended results. That is the case of blocking EGFR during wounding and the effect it has in normal scalp, and something very interesting actually dkk1, one of the nastiest stuff for normal scalp hair actually allows new hair to get pigmented by inhibiting wnt1 (now how about that one eh):
This seems to indicate that by introducing an anti-androgen in the wound that down regulates DHT, you might actually blunt dkk1 expression in the wound and prevent new follicles to get pigmented.
Wb Rambo, so based on this es finding, it says that we may be actually destroying healthy follicles?
So what does it look like now. In your opinion, what is the most educated protocol you would advice in terms of time and topicals. I have t admit, I have been shedding really bad the last two weeks, it's kinda scary. I thought I had things under control.
