princessRambo
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@jorged: stem cells are activated by the adipocytes as the yell study pointed out.
Since the derma-roller thread has become a troll fest of broscience and non contextual studies popping everywhere to make a point that isn't relevant to hair growth, I thought I would clear up a confusion between hair regeneration and de-novo hair formation also known as fair follicle neo genesis.
In an layman's term the difference is this: It's like a chicken and eggs analogy.
It was though we were born with a limited about of hair follicles. Before going further, people should realize the hair follicle is not the hair we talk about in forums, what we see bursting through the epidermis is the hair shaft, and not the hair follicle itself, it is only a structure of the follicle. The follicle itself is an amazingly complex mini organ, people tend to think of hair follicle as a cell, but it is not, it is a complex organ comprising many structures, including, the dermal papilla, sebaceous gland, bulge region containing stem cells for regeneration, etc. What we see is the shaft. That said. Let's go back to the chicken and egg analogy. It was previously thought that we were born with a limited numbers of these hair follicles/mini organs at birth. These follicles are self sustaining, they contain a reproductive system to ultimately regenerate the hair shaft through morphogenesis using stem cells in the bulge area of the mini organ (follicle).
Here is a description of the process that takes place before neo-genesis.
Hair regeneration on the other hand is highly dependent of existing stem cells in the bulge area of the already existing follicle.
http://www.sciencedirect.com/science/article/pii/S1534580705004259
Essentially it was thought before that when the chicken loses her ability to give eggs (hair shaft), you go bald. Recently it was found that we can in fact create new chicken or hair follicle mini organs through wound healing and activation of certain growth factors when timed perfectly. This is an incredibly complex process that doesn't occur in human without endogenously introducing certain growth factors, timed perfectly. A simple way to look at it is this: assume you lose a limb, in regeneration, you regenerate a new limb. In neogenesis, you yourself are created anew. Two very distinct things.
So simply dermarolling or wounding does not induce neogenesis, there isn't a single study supporting such thing.
The yale study found that it was possible even after the hair follicle stem cells went dormant, it was possible to reactivate the dormant stem cells from fat tissues below the hair follicle. This again is regeneration and not neogenesis. The problem is that fat tissues growth is relative to hair growth. In other words, when hair enters into anagen, adipogenesis occurs and fat tissues expend, when hair enters into telogen, fat tissues shrink. This is one of reason why in balding scalp, where we have an insane amount hair in premature telogen, the skin feels so thin compared to the hairy areas.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298746/
- - - Updated - - -
In other news, I think I will make full recovery by Christmas the way my hair is growing, some relatives I haven't seen since last Christmas will likely pull my hair thinking I am wearing a wig :woot:
Since the derma-roller thread has become a troll fest of broscience and non contextual studies popping everywhere to make a point that isn't relevant to hair growth, I thought I would clear up a confusion between hair regeneration and de-novo hair formation also known as fair follicle neo genesis.
In an layman's term the difference is this: It's like a chicken and eggs analogy.
It was though we were born with a limited about of hair follicles. Before going further, people should realize the hair follicle is not the hair we talk about in forums, what we see bursting through the epidermis is the hair shaft, and not the hair follicle itself, it is only a structure of the follicle. The follicle itself is an amazingly complex mini organ, people tend to think of hair follicle as a cell, but it is not, it is a complex organ comprising many structures, including, the dermal papilla, sebaceous gland, bulge region containing stem cells for regeneration, etc. What we see is the shaft. That said. Let's go back to the chicken and egg analogy. It was previously thought that we were born with a limited numbers of these hair follicles/mini organs at birth. These follicles are self sustaining, they contain a reproductive system to ultimately regenerate the hair shaft through morphogenesis using stem cells in the bulge area of the mini organ (follicle).
Here is a description of the process that takes place before neo-genesis.
Hair regeneration on the other hand is highly dependent of existing stem cells in the bulge area of the already existing follicle.
http://www.sciencedirect.com/science/article/pii/S1534580705004259
Essentially it was thought before that when the chicken loses her ability to give eggs (hair shaft), you go bald. Recently it was found that we can in fact create new chicken or hair follicle mini organs through wound healing and activation of certain growth factors when timed perfectly. This is an incredibly complex process that doesn't occur in human without endogenously introducing certain growth factors, timed perfectly. A simple way to look at it is this: assume you lose a limb, in regeneration, you regenerate a new limb. In neogenesis, you yourself are created anew. Two very distinct things.
So simply dermarolling or wounding does not induce neogenesis, there isn't a single study supporting such thing.
The yale study found that it was possible even after the hair follicle stem cells went dormant, it was possible to reactivate the dormant stem cells from fat tissues below the hair follicle. This again is regeneration and not neogenesis. The problem is that fat tissues growth is relative to hair growth. In other words, when hair enters into anagen, adipogenesis occurs and fat tissues expend, when hair enters into telogen, fat tissues shrink. This is one of reason why in balding scalp, where we have an insane amount hair in premature telogen, the skin feels so thin compared to the hairy areas.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298746/
- - - Updated - - -
In other news, I think I will make full recovery by Christmas the way my hair is growing, some relatives I haven't seen since last Christmas will likely pull my hair thinking I am wearing a wig :woot:
