Nothing seems to work, growing more frustrated and feeling lost

[Mr. Slap Head]

Post the study. So simple like that . And we can all read it here . Dutasteride have a 5 week half life while Finasteride only 7 hours , plus , Dutasteride inhibit All the DHT that Finasteride Inhibit , by the exactly same mechanism PLUS a 29 % more since it inhibit both 5-alpha reductase type 1 and 2 . Hence , you are an ignorant . Using Science like it was a religion .

Do you believe that inhibitors can cause upregulation of AR?

 

[Adri23]

Cause you are an Ignorant, again, the problem is your brain. If you don't have enought minoxidil sulphate convertion enzyme, not matter how much you use, it will not work. That is why tretinoin is a much better alternative and this is why topical tretinoin plus minoxidil is better than minoxidil oral.

Man I'm done with you. I don't know if you didn't know but your liver does the work of sulphate convertion enzyme because it actually has the enzymes to do it. That is why oral minoxidil works on everyone.

Sulfation of minoxidil by human liver phenol sulfotransferase - PubMed

The N,O-sulfate of minoxidil (Mnx) is the active agent in producing the vasodilation and the hair-growth stimulating responses observed with Mnx treatment. In this report, Mnx sulfation activity was assayed in cytosol prepared from several normal human livers, and Mnx sulfation was shown to...

pubmed.ncbi.nlm.nih.gov

Next time you talk, go to pubmed.gov page (yeah the page you suggested me to search for information).

 

[Mr. Slap Head]

Man I'm done with you. I don't know if you didn't know but your liver does the work of sulphate convertion enzyme because it actually has the enzymes to do it. That is why oral minoxidil works on everyone.

Sulfation of minoxidil by human liver phenol sulfotransferase - PubMed

The N,O-sulfate of minoxidil (Mnx) is the active agent in producing the vasodilation and the hair-growth stimulating responses observed with Mnx treatment. In this report, Mnx sulfation activity was assayed in cytosol prepared from several normal human livers, and Mnx sulfation was shown to...

pubmed.ncbi.nlm.nih.gov

Next time you talk, go to pubmed.gov page (yeah the page you suggested me to search information).

These forums are becoming a joke man. We got people spreading ridiculous misinformation all over the place. Seems like these people just want to see others go bald faster.

 

[Adri23]

These forums are becoming a joke man. We got people spreading ridiculous misinformation all over the place. Seems like these people just want to see others go bald faster.

That is exactly what they want. They didn't catch their hair loss at time so they are already NW3 at least, so they want you to be at least NW3 or more

 

[jamesbooker1975]

Man I'm done with you. I don't know if you didn't know but your liver does the work of sulphate convertion enzyme because it actually has the enzymes to do it. That is why oral minoxidil works on everyone.

Sulfation of minoxidil by human liver phenol sulfotransferase - PubMed

The N,O-sulfate of minoxidil (Mnx) is the active agent in producing the vasodilation and the hair-growth stimulating responses observed with Mnx treatment. In this report, Mnx sulfation activity was assayed in cytosol prepared from several normal human livers, and Mnx sulfation was shown to...

pubmed.ncbi.nlm.nih.gov

Next time you talk, go to pubmed.gov page (yeah the page you suggested me to search for information).

Lol. INVITRO study. Here you have it boy. Hold my beer , IN VIVO STUDY :

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - PubMed

Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra-subject variability in follicular...

pubmed.ncbi.nlm.nih.gov

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

 

[jamesbooker1975]

These forums are becoming a joke man. We got people spreading ridiculous misinformation all over the place. Seems like these people just want to see others go bald faster.

What is the missinformation ? Minoxidil is a drug available since the late 1970 . Can you post a single study that is show that person who don't respont to topical minoxidil respond to oral minoxidil ? If the activation of the enzyme is low in the person follicle, most probably will be low in the liver.
You really think that this drug, with almost 50 years !!! on the market nobody tried it oral Before !? REally !??!!?!?!?!?!?!

 

[jamesbooker1975]

And before some IDIOTS start to drink your tretinoin creams, or using oral isotretinoin, you need it to use it topical ! Oral is an extremly stupid and lazy way to use it minoxidil, that, by the way, was already tried it over and over . Search for the old post of early 2000 in hairsite . Already tried it