Published in Nature: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

[trialAcc]

Maintenance is overrated though, especially in these short-term studies.

Some people more or less 'maintain' for 10 years with no treatment. If it can give at least 5% regrowth that would be something to talk about, so hopefully it delivers regrowth even if minor.

I feel like you don't have a solid grasp on the clinical trial process. When the placebo group declines 5% in density and the trial arm increases in that same time period, that's your result. You can't apply dumb platitudes like "some maintain for years with nothing!" when comparing two mean data sets that are going in different directions.

By your own logic, finasteride doesn't work either because some people maintain for that 5~ year period without it. This trial showed slightly lesser results then finasteride in a similar period of time.

 

[Kagaho]

I quickly read the study, but can't find where that 83% exactly comes from and what it means. If true, that fact sheet is misleading.

However, if this is indeed a viable option, we will hear more than enough about it in the coming months.

Its about hair count. They compared it with a 6 month finasteride trial and got 83% Finasteride results.

I think this is a promising treatment but they have a long way to go just to prove they can achieve long term maintenance.

 

[Super Metroid]

Its about hair count. They compared it with a 6 month finasteride trial and got 83% Finasteride results.

I think this is a promising treatment but they have a long way to go just to prove they can achieve long term maintenance.

The factsheet says that cosmerna regrew 1.9 hairs per cm2 per month and finasteride 1.6

After 4 months, cosmerna subject had 7.6 more hairs per cm2, while finasteride users had 9.3 after 6 months

7.6 is roughly 83% of 9.3, but you cant compare those results because of the different timeframes.

That, or the factsheet is simply wrong.

Anyway, doesn't really matter that much. Lets hope we hear more about it.

 

[Dimitri001]

So, if I'm reading this right, only 44 male participants, all told? Not great for testing efficacy and certainly not great for testing for rare sides. With that small a sample size, maybe finasteride wouldn't show any sides, either.

 

[Baldingtooyoung]

Its about hair count. They compared it with a 6 month finasteride trial and got 83% Finasteride results.

I think this is a promising treatment but they have a long way to go just to prove they can achieve long term maintenance.

If this is a cosmetic product they do not have to prove anything if they don't make any claims.

That's the only thing i do not understand about it actually

 

[Flamingflaps]

If this is a cosmetic product they do not have to prove anything if they don't make any claims.

That's the only thing i do not understand about it actually

Do you mean you’re not sure why they’re trying to prove anything before release? I guess if they have proof, it’ll sell better initially than it would without!

guess I’ll be stacking this with finasteride. Hopefully stacking improves results of either alone.

 

[Baldingtooyoung]

Do you mean you’re not sure why they’re trying to prove anything before release? I guess if they have proof, it’ll sell better initially than it would without!

guess I’ll be stacking this with finasteride. Hopefully stacking improves results of either alone.

But why then sell it cosmetical when it's so effective for a "medicial condition"

 

[Kagaho]

It could very well be both cosmetical and pharmaceutical.

Maybe nucleic acid based therapies can be designed in a way they do not affect the body as much as classic small molecules?

 

[Baldingtooyoung]

It could very well be both cosmetical and pharmaceutical.

Maybe nucleic acid based therapies can be designed in a way they do not affect the body as much as classic small molecules?

No.
You can not do both together.

 

[Kagaho]

No.
You can not do both together.

What are cosmeceuticals then? By definition cosmetic products with bioactive ingredients purported to have medical benefits. So, despite not having to "prove" it legally speaking, they may have pharma grade efficacy as well.

This company is using that angle for marketing porpuses, looking at the presentation posted in this very same thread. If they can actually prove they have something comparable to Propecia without side effects, they are sitting on a goldmine and they know it.

 

[Baldingtooyoung]

What are cosmeceuticals then? By definition cosmetic products with bioactive ingredients purported to have medical benefits. So, despite not having to "prove" it legally speaking, they may have pharma grade efficacy as well.

This company is using that angle for marketing porpuses, looking at the presentation posted in this very same thread. If they can actually prove they have something comparable to Propecia without side effects, they are sitting on a goldmine and they know it.

Yes, that's why it is weird that it's cosmetical and not pharmaceutical.
Hence my point.

 

[Kagaho]

Yes, that's why it is weird that it's cosmetical and not pharmaceutical.
Hence my point.

Bcs with the cosmetical label they dont have to waste years and millions on clinical trials. A good Phase 3 study is enough to at least partially prove what they are claiming. Thats why they published some of their data in Nature, legitimacy sells.

 

[Baldingtooyoung]

Bcs with the cosmetical label they dont have to waste years and millions on clinical trials. A good Phase 3 study is enough to at least partially prove what they are claiming. Thats why they published some of their data in Nature, legitimacy sells.

They already done multiple human studies. I've you can get this trough pharmaceutical route, you could ask A LOT more cash than cosmetical.

 

[kiwi666]

It's nothing spectaculair that's for sure.

f**

 

[kiwi666]

"Nanoparticles can be more efficiently delivered to hair follicles than small molecules through the pumping effect of massage after application"

IMO, No regrowth but maintenace due at massaging scalp 3 times a week.

But the images show regrowth

 

[Flamingflaps]

But why then sell it cosmetical when it's so effective for a "medicial condition"

Why wouldn’t you sell as a cosmetic if you can? They’re surely not gonna put it through years of expensive trials if it’s not required…

 

[Paqua]

I live in germany and will try to join this trial

If it works I will keep you guys updated

I contacted them but the woman responsible for the study did not call me back so far because she is "very busy"

 

[Armando Jose]

But the images show regrowth

Little regrowth in case

 

[Baldingtooyoung]

Why wouldn’t you sell as a cosmetic if you can? They’re surely not gonna put it through years of expensive trials if it’s not required…

Already explained this two times now.

 

[Ralph Wiggum]

I contacted them but the woman responsible for the study did not call me back so far because she is "very busy"

Thank you for your efforts.