RIKEN Announcement: Succeeded in Developing Tech for HF Regenerative Medicine: Study to be Published Feb 10

trialAcc

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I'm not saying there's no one interested.
I'm saying that with proof in humans investors would throw their money to them, just that.
I just don't really understand the apologists for how they've chosen to go about this lol. This is almost undoubtedly a negative sign that they would be asking for donations on twitter, yet people have given every excuse possible for why they'd be doing this and when they could see investors.
 

trialAcc

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People hate my opinion, but HM/HC won't happen ever in "near future" There are life-threatening conditions, like cancer etc, which need to be considered first, than cosmetical issues.
Well probably because this opinion just doesn't make sense lol. There is the ability to work on more then 1 thing at a time, and the money to do so as well.
 

Selb

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Even if it costs 200k, I’d take a loan out. Think about how much time you spend thinking about hair loss. Time > money. And this is something I’m realizing more and more by the day
 

frank33

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I just don't really understand the apologists for how they've chosen to go about this lol. This is almost undoubtedly a negative sign that they would be asking for donations on twitter, yet people have given every excuse possible for why they'd be doing this and when they could see investors.
I don't like that too, but i think we can't judge without knowing the full story.
Honestly the most surprising part of all of this is the fact they are only asking for 5 million, while stemson needs 3 times that for their pigs preclincal study.
 

Pls_NW-1

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Well probably because this opinion just doesn't make sense lol. There is the ability to work on more then 1 thing at a time, and the money to do so as well.
Probably many investors and VC are just more interested into a good treatment for cancer than a "its a cure" tweet/slogan. It's my personal opinion.
 

WaccWaccWacc

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You do realize that most people don't have over 200k follicles on their heads? What would you be going for with 600,000 o_O

I agree though, I need human proof before I change anything in the present (ie get a hair transplant).
Oh I realize. That’s why people say “infinite”, because relatively it is. However with avg 6k donor zone, 100x per each follicle implies 600,000k follicles harvested and cultured... if it works like that. No idea.

also Riken announced that their preclinical safety test on a human was successful. However I need mass human proof till I start booking hair transplants, hopefully thats within the next 2 years.
 

WaccWaccWacc

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I just don't really understand the apologists for how they've chosen to go about this lol. This is almost undoubtedly a negative sign that they would be asking for donations on twitter, yet people have given every excuse possible for why they'd be doing this and when they could see investors.
You don’t see how it would be beneficial to not pay interest or dilute ownership of your company to borrow money when you could just ask people who are willing to give you money?
 

soull

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You do realize that most people don't have over 200k follicles on their heads? What would you be going for with 600,000 o_O

I agree though, I need human proof before I change anything in the present (ie get a hair transplant).

I think they are trying to advertise with the donations and are partially succeeding
 

trialAcc

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You don’t see how it would be beneficial to not pay interest or dilute ownership of your company to borrow money when you could just ask people who are willing to give you money?
Yeah sure in a imaginary world, but in real life it's going to take 10s of millions more to bring this to market and pass regulatory hurdles around the globe and even in Japan. A company like this should have structured partnerships with investors to craft that business process WHILE they go through the clinical trials process. What you just said is the equivalent of a grant in the business world, which I would not have a problem with if they received.

The way this is being pursued just leaves me to believe that even if they are able to drag this successfully through trials that we'd see a major hurdle with actually seeing it available anywhere at all. More likely they fail during trials because they don't have money and didn't create relationships with strategic investors, though.
 

czecha

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This is basically whats happening in every research lab/center. Researchers are working towards the next funding period, meaning they have to impress the people who grant those budgets. The result orientation of research labs isn't what people think it is. The result they are working towards is funding, first. The result they are working for is getting regular paychecks in for a longer period.

So we know this is a billion dollar idea, and they only need 5 mil. Rikens budget is like 800 mil/year (I think). So what you'd do first is try to get money from the Riken pool, obviously.

Now perhaps this years money is already spent/planned with, although it's hard for me to believe that they wouldn't be getting the money immediately when the payout is so large if you could convince the people who allocate the budgets at Riken with actual hair grown on a human. You'd be surprised how quickly 5% of a yearly budget is suddenly available when you have a promising billion dollar idea. At the very least, they should be getting this money 2022, and tbh they should be getting it if their idea even had only a 5% chance of working.

So the problem is that they are not convincing for Rikens internal expert panels allocating the money. There is no way some scientists who produce results are like "yep, lets ask for donations for a cosmetic issue instead for money from our firm".

You don't need advertising through a call for donations. That's just unprofessional. Shocking, really. Grow hair on a human being, and the whole world is looking at you.

Another day, another hair loss money grabbing strategy.
 

Pls_NW-1

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Then why are VC firms funding other "cure" like treatments for hairloss? Stemson has VC seed funding, Moogene does as well.
Maybe they don't even rank tsujis solution as THE solution. I wonder if Stemson will even get their needed funds... Money is always the problem, we live in a cruel world. If people really want to push this research to an end, even governments should "properly" invest into it.
 

WaccWaccWacc

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Yeah sure in a imaginary world, but in real life it's going to take 10s of millions more to bring this to market and pass regulatory hurdles around the globe and even in Japan. A company like this should have structured partnerships with investors to craft that business process WHILE they go through the clinical trials process. What you just said is the equivalent of a grant in the business world, which I would not have a problem with if they received.

The way this is being pursued just leaves me to believe that even if they are able to drag this successfully through trials that we'd see a major hurdle with actually seeing it available anywhere at all. More likely they fail during trials because they don't have money and didn't create relationships with strategic investors, though.
Time will tell.
 

trialAcc

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This is basically whats happening in every research lab/center. Researchers are working towards the next funding period, meaning they have to impress the people who grant those budgets. The result orientation of research labs isn't what people think it is. The result they are working towards is funding, first. The result they are working for is getting regular paychecks in for a longer period.

So we know this is a billion dollar idea, and they only need 5 mil. Rikens budget is like 800 mil/year (I think). So what you'd do first is try to get money from the Riken pool, obviously.

Now perhaps this years money is already spent/planned with, although it's hard for me to believe that they wouldn't be getting the money immediately when the payout is so large if you could convince the people who allocate the budgets at Riken with actual hair grown on a human. You'd be surprised how quickly 5% of a yearly budget is suddenly available when you have a promising billion dollar idea. At the very least, they should be getting this money 2022, and tbh they should be getting it if their idea even had only a 5% chance of working.

So the problem is that they are not convincing for Rikens internal expert panels allocating the money. There is no way some scientists who produce results are like "yep, lets ask for donations for a cosmetic issue instead for money from our firm".

You don't need advertising through a call for donations. That's just unprofessional. Shocking, really. Grow hair on a human being, and the whole world is looking at you.

Another day, another hair loss money grabbing strategy.
Exactly. It's almost unbelievable to me to see a company that thinks they have a real cloning procedure figured out in the time of a boom in the hair transplant industry globally have to resort to asking for donations on social media. I don't know if its a scam or just wildly unprofessional but either way it's completely killed any hype I for the procedure.
 

trialAcc

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Maybe they don't even rank tsujis solution as THE solution. I wonder if Stemson will even get their needed funds... Money is always the problem, we live in a cruel world. If people really want to push this research to an end, even governments should "properly" invest into it.
No one cares if its "the solution", that's not how investing works. Just if it has the potential for a return on investment.
 

Pls_NW-1

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I think Stemson's approach may also be more lucrative for investors because you have to repeat the treatment every few years. I fear mutations.
They even said that themselves. Most likely the bioengineered follicle is just not capable of keeping an on-going life-cycle.
 

pegasus2

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No they didn't, the tweet your most likely referring to looks like a bad translation. This is from the information on their donation page: https://www.riken.jp/medialibrary/r...ive/Regenerative_medicine_project_outline.pdf

"In this project, we will promote new basic research to realize the pertinent treatment, and also cooperate in human clinical studies as the world's first Japanese organ regeneration medicine of "hair regeneration medicine" for which safety has already been confirmed in animal experiments."

You can't do a pre-clinical safety tests on humans. Phase 0 of clinical trials is for safety in humans.
Phase 0 is probably what they are referring to. It doesn't take much money, and they already have approval for it so it's not hard to believe the translation is correct.
 

pegasus2

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Doubt it tbh, the fact that they mention safety has been confirmed in animal experiments leads me to beleive thats the point they're at, next step would be phase 0. Saying all this, I'm not totally familiar with the Japanese trial process even more so the fast tracked stem cell trials.

Either way, I don't think they've done safety in humans yet, they'd of told us if they had IMO.
They did tell us, but you think it's a translation error. We just went in a circle.
 

jan_miezda

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Even in November when they make a skin tissue analog they didn’t receive any additional investment. They are taking a different business approach
 

pegasus2

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It stands to reason it was a translation error, auto-translate is notoriously bad with japanese/english translation.

What also supports this is that all the materials they put out alongside it contradicts them having done phase 0 of clinical trials.

The previous quote mentioned, aswelll as this - https://www.riken.jp/en/news_pubs/research_news/pr/2021/20210210_3/index.html

"As preclinical animal-safety tests using these cultured cells were completed in 2019, the next step in the process is clinical trials."
Like I said, we just went in a circle, and now you're doing the same circle again. Your argument didn't convince me the first time, so it stands to reason I won't be convinced this time either. I already said it could be a translation error. We will just have to wait and see.
 
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