First of all, nothing on the planet can override darolutamide. It's the strongest thing there is. Not even aggressive prostate cancers can beat it, as long as they are androgen dependent.
It is true that androgen deprivation/blockade will likely lead to upregulation of androgen receptors. But the only studies I've seen on it suggest it's a transient and weak process. I haven't researched it too extensively because it's simply not something I worry about or think is anything to worry about based on what I've seen.
As an example,
this was an animal study of how castration (both physical - cutting off the nuts, and chemical with the androgen receptor antagonist flutamide, etc.) affected androgen receptor expression in the prostates of rats.
Here was their primary finding on physical castration, which matched what they saw with chemical castration:
View attachment 71244
In other words, there was a temporary increase in androgen receptor expression after the castration, but it went back to normal levels within a week.
Here is what they had to say about it:
View attachment 71245
View attachment 71246
So like I said, it's not something I worry about.
PRP is okay for growth stimulation effect. I had some standard PRP done a few years ago. But for male pattern baldness, you must find a solution to the androgen problem above all else or things like PRP won't make a difference. PRP is like icing on a cake.