Verteporfin drug induced scarless healing with new hair follicles on mice. This new founding can be really big

[Follisket]

Does anyone know whether Follica is aware of the recent discoveries regarding Verteporfin? My hopes for them were never particularly big, but the fact that they have the device pretty much ready while supposedly struggling to find a superior growth stimulant to minoxidil could make this a perfect match (and hopefully lead to a relatively fast market release?). I would imagine they, at very least, have an incentive to test this quicklacy.

 

[DuncanOP]

Interesting that they mention it can be used with strip surgeries (FUT’s). But also with smaller wounds such as FUE’s. And even microneedling:

«A method including injection of Verteporfin following micro-injury of a region of alopecia (via Fraxel, microneedling, or other similar approaches) may be used to promote increased hair regrowth in the region. This method does not require grafting of active hair follicles from other regions of skin but could instead encourage true de novo hair folliculogenesis in an otherwise hairless area.»

But it is in mouse, not in humans, right?
It is not tested in humans yet, anyway, looks very promising

@Follisket​

My hopes for them were never particularly big, but the fact that they have the device pretty much ready while supposedly struggling to find a superior growth stimulant to minoxidil could make this a perfect match

Sorry, I didn't get your point. Verteporfin should heal scar and stimulate the recover of UF. So it is not related to regrowth.

Plus I think it should be injected to relative deep into scalp. I mean, a "simply dermaroller" isn't enough to do it. A chirurgical approach could be necessary to inject Verteporfin

 

[FollicleGuardian]

But it is in mouse, not in humans, right?
It is not tested in humans yet, anyway, looks very promising

@Follisket​

Sorry, I didn't get your point. Verteporfin should heal scar and stimulate the recover of UF. So it is not related to regrowth.

Plus I think it should be injected to relative deep into scalp. I mean, a "simply dermaroller" isn't enough to do it. A chirurgical approach could be necessary to inject Verteporfin

You can use FAK inhibitors which does not need to be injected.

the approach is tested in pigs which is the big hurdle. As their skin and scarring mechanisms are extremely similar to human skin.

 

[FollicleGuardian]

Does anyone know whether Follica is aware of the recent discoveries regarding Verteporfin? My hopes for them were never particularly big, but the fact that they have the device pretty much ready while supposedly struggling to find a superior growth stimulant to minoxidil could make this a perfect match (and hopefully lead to a relatively fast market release?). I would imagine they, at very least, have an incentive to test this quicklacy.

Why would they cooperate with Follica? Stanford has the cure, and the intellectual property to this. Follica has an overhyped microneedling device.

 

[DAVAT]

We have to share this study to follicle thought and hlc2020 or to dermatologists/doctors directly

Hair Loss Cure 2020 | Hair loss blog with the latest news updates.

Stay up-to-date on the latest breakthroughs in hair growth and regeneration. Get key insights on hair loss cures at Hair Loss Cure 2020.

www.hairlosscure2020.com

Hairlosscure2020 is already covering it

FAK Inhibitor for Hair Loss​

I saved the most important news for last. In recent days, a few people discussed this Stanford University research (first posted by “DrPhil”) on our hair loss chat.

FAK inhibitor skin healing and hair follicle regrowth at 180 days. Source: Nature Communications.
The researchers found that blocking mechanical signaling via FAK (focal adhesion kinase) inhibition promotes regenerative skin healing.

 

[Janks16]

What am I looking at. Hard to see.

 

[glammetal]

*yawn* Wake me up when HMI-115 is available. That's at least been proven to grow long, thick terminal hairs in primates. I must have seen nearly a dozen studies over the years of mouse excisions healing with new hair. I've yet to see it in humans. This is quite promising for skin regeneration, but I won't hold my breath for terminal hair

Yes but their site is not working for many months.

 

[FollicleGuardian]

What am I looking at. Hard to see.

Pig skin. The gold standard model of skin research. Closest to humans. The picture lowest is the one pig that is treated with a FAK inhibitor. The two above are non treated pigs.

 

[pegasus2]

Pig skin. The gold standard model of skin research. Closest to humans. The picture lowest is the one pig that is treated with a FAK inhibitor. The two above are non treated pigs.

Amazing how much hair the non-treated pigs regenerated for an animal whose skin is just like humans. It's almost as if their skin wounds express different molecular signals to begin with

 

[hairlossisevil]

Amazing how much hair the non-treated pigs regenerated for an animal whose skin is just like humans. It's almost as if their skin wounds express different molecular signals to begin with

Yeah, there's a lot of hair regrowth even on non treated wounds. So much for pig skin is very close to human skin.

 

[FollicleGuardian]

I see 0 hair in the non treated ones

 

[hairlossisevil]

I see 0 hair in the non treated ones

You don't? Look how large the wound was. And how much smaller it becomes. Are those not shaved regenerated hairs?

https://imgur.com/a/Av4IVro

 

[FollicleGuardian]

You don't? Look how large the wound was. And how much smaller it becomes. Are those not shaved regenerated hairs?

https://imgur.com/a/Av4IVro

That’s not hair. They didn’t shave any of the pigs POD. All wounds contract themselves.

 

[hairlossisevil]

That’s not hair. They didn’t shave any of the pigs POD. All wounds contract themselves.

You do that on a human and you get a perfect rectangle of nothing but scar tissue.

 

[pegasus2]

Every scientist wants to hype their findings so they can get more funding. Always take it with a grain of salt

 

[FollicleGuardian]

You do that on a human and you get a perfect rectangle of nothing but scar tissue.

You really don’t if there is mechanical stretching. Look at FUT scars.

 

[FollicleGuardian]

FUTs are stitched up

There’s a reason for it. To not get stretches. There’s always tension. In these pigs there’s a lot of it.

 

[FollicleGuardian]

I'm going to say this one more time because I care about you bro. You gotta stop coping. It's not healthy. Maybe we can do an intervention for you on discord

Haha bro lmao <3

 

[Diffused_confidence]

They were much bigger excisions than what's remaining bald

I think that may be due to the wound being deeper in some areas. There is a diagram of the wounds and the outer layer doesn't go into the dermis it seems. Maybe that's why there is some regrowth around the border?

 

[-specter-]

I believe that at this point the only answer can come by testing the procedure on humans and seeing what happens. I have enough faith in this theory because as I said in the past I know of people who have been "treated" with herbal concoctions in Sardinia who have experienced healing from burns and wounds with a lot of hair regrowth. Now we have never managed to deal with it with the pharmaceutical companies, but if a farmer in a remote place has succeeded, I do not see why the product of serious scientific research cannot work.