Verteporfin drug induced scarless healing with new hair follicles on mice. This new founding can be really big

Zon Ama

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Okay, I thought its too early to say if it works. I was expecting regrowth in the donor area after using verteporfin, so that we can have some regeneration of the donor area to use the regenerated hair in following transplants
 

jjoshh8

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this seems amazing for hairline reduction surgery, which is arguably the best way to have thickest natural hairline ever without using *ANY* donor graft at all. The problem is it sucks because of the visible scar... but... if Verteporfin produces a scarless incision it would become extremely valuable option to consider. It can save you at least 3-4K grafts and is way cheaper than hair transplant. Results are immediate.

some examples of forehead reduction incisions
View attachment 182672

View attachment 182673

What a joke, pictures show nothing
 

RagnarLothbrok

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right after surgery
1658238354624.png
healed months later

1658238334108.png


If you can produce 0 scar tissue with Verteporfin and advance your scalp 2-3cm you would save up to 3k follicles with no downsides. Seems pretty useful to me.

And don't forget you can actually implant hairs in the scar area and hide the whole scar if Verteporfin produces healthy skin. (Usually scar tissue is not optimal for transplanting)
 

jjoshh8

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are you dumb, what do you want to see other than it is shown, its a hairline advancement lol
Check again. Picture 1, lighting issues and top of the head almost cut off. Picture 2, his hair is pulled back then the after is just loose

these pics were probably taken the same day and just edited.
 

RagnarLothbrok

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Check again. Picture 1, lighting issues and top of the head almost cut off. Picture 2, his hair is pulled back then the after is just loose

these pics were probably taken the same day and just edited.
What is even your point, forehead reduction surgery is really easy and minimally invasive, its obvious all you need to do is cut a bit of skin, pull it together, reduce your hairline and it saves you thousands of follicles. The only reason its not more popular is because the ugly scar it leaves in your forehead but Verteporfin could solve this. Who cares about result images, its just images to illustrate the point.
 

Fgsfds

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If you can produce 0 scar tissue with Verteporfin and advance your scalp 2-3cm you would save up to 3k follicles with no downsides. Seems pretty useful to me.

And don't forget you can actually implant hairs in the scar area and hide the whole scar if Verteporfin produces healthy skin. (Usually scar tissue is not optimal for transplanting)
infinite hair glitch
 

coolio

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If you can produce 0 scar tissue with Verteporfin and advance your scalp 2-3cm you would save up to 3k follicles with no downsides.

That would not save anything.

After the procedure was over,
1. You would not have gained any more total follicles on your head.
2. Your skull would not be any smaller.

Any new hair coverage on the front of your head must have come from stretching out the scalp skin tighter over the rest of your head. That means it was thinning the follicle density like a normal transplant surgery.
 

RagnarLothbrok

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Lmao, it doesnt thin out density at all. None.

Reducing hairline by 3 cm needs around 2.5k follicullar units if you did a hair transplant, which depletes half of a normal healthy donor.
So you save those follicles from your donor, and can still use them for a more striking result in your hairline still.
Its not that lowering your hairline will increase the amounts of folicles in your head, it is that you need less follicles for the same cosmetic effect.
A hair transplant is an illusion to trick our brains after all, a normal transplant has 60-80FU/cm2 density while a real head of hair has >120 FU/cm2 density. The brain can not distinguish a full head of hair past some threshold density thats why we are late to notice hair loss most of the time. Moving your scalp doesn't produce any visible thinning. Just pull down your forehead skin right now and see if you hair becomes thinner.

And of course its not gonna help someone who is NW6 and the hair behind his NW2 is also sh*t. Most transplants are focused on hairline restoration and hairline lowering. If Verteporfin produces 0 scars this will be huge for most people. But I doubt Verteporfin can produce 0 scars, it sounds like black magic.
 
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coolio

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Lmao, it doesnt thin out density at all. None.

Then it has to either create more follicles or make your skull smaller. Pick one.

Reducing hairline by 3 cm needs around 2.5k follicullar units if you did a hair transplant, which depletes half of a normal healthy donor.
So you save those follicles from your donor, and can still use them for a more striking result in your hairline still.
Its not that lowering your hairline will increase the amounts of folicles in your head, it is that you need less follicles for the same cosmetic effect.
A hair transplant is an illusion to trick our brains after all, a normal transplant has 60-80FU/cm2 density while a real head of hair has >120 FU/cm2 density. The brain can not distinguish a full head of hair past some threshold density thats why we are late to notice hair loss most of the time. Moving your scalp doesn't produce any visible thinning. Just pull down your forehead skin right now and see if you hair becomes thinner.

And of course its not gonna help someone who is NW6 and the hair behind his NW2 is also sh*t. Most transplants are focused on hairline restoration and hairline lowering. If Verteporfin produces 0 scars this will be huge for most people. But I doubt Verteporfin can produce 0 scars, it sounds like black magic.

Translation: "Yes it it does thin out density. But it won't show".


Better solution:

Get a normal FUE transplant. Have the doctor harvest donor follicles from your entire non-balding area, including the "safe zone" and otherwise. Some of those hairs will eventually be prone to thinning. But as long as they are placed evenly scattered throughout the recipient areas, that won't end up looking strange. Your whole head will just have more gradual thinning from age. The trade-off is that you can spend your younger years with more hair cosmetically restored for a while.
 

bigentries

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Wonder why no one is talking about the latest results posted in follicle thought
There is some early evidence of regeneration with FUE. If the following weeks confirm it, this is the craziest thing I’ve seen in over a decade of following potential hair loss treatments

I’m even wondering if verteportin would regenerate hair from dermarrolling or dermabrasion
 

coolio

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The idea of regeneration after FUE - tread carefully. There has been a ton of deceptive evidence & bullshit claims on that in the past.

Pulling out a 3-hair follicular unit from the donor area, and getting 1 new hair to grow from the wound? It's not progress unless all 3 of the original hairs survived on top. If only 2 of them survived then you broke even. If 1 of them survived then you lost hair.

This includes partials. Like, they transplanted a 3-hair unit, and a thinner-looking "new" hair grows from the wound. But one of the recipient hairs coincidentally happens to look thinner now too. Again, this has been done before and it's not progress. It's only progress when the net total amount of hair density on the patient's whole head increases.
 
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RagnarLothbrok

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The idea of regeneration after FUE - tread carefully. There has been a ton of deceptive evidence & bullshit claims on that in the past.

Pulling out a 3-hair follicular unit from the donor area, and getting 1 new hair to grow from the wound? It's not progress unless all 3 of the original hairs survived on top. If only 2 of them survived then you broke even. If 1 of them survived then you lost hair.

This includes partials. Like, they transplanted a 3-hair unit, and a thinner-looking "new" hair grows from the wound. But one of the recipient hairs coincidentally happens to look thinner now too. Again, this has been done before and it's not progress. It's only progress when the net total amount of hair density on the patient's whole head increases.
Thats not how follicle neogenesis works. In this trial the follicles taken from the donor were **completely removed** in its whole entirety. Gone. No follicle cells left. No transections. The follicle is literally gone, there is nothing to "rebuild" in that sense, so every new hair sprouted is already a positive gain.

That is what is mindblowing about this trial. A follicle magically can grow out of nowhere. The process involved is called "quorum sensing" where nearby cells can signal to new forming cells which cell it should be. Obviously the fact that before there was a follicle existing there also helps in the whole process.

If a new hair grows that didn't even exist to begin with it is to be celebrated, and there's no scientific evidence that it should contain the exact same amount of hairs as the extracted one. We yet have to see if they will manage to become full terminal though.

Nonetheless, it is very positive news so far only 8 weeks in and esp. considering this proof of concept trial in human is not even the same as was used in mice and pig. (Donor was depleted via skin patch removal and not small FUE holes which could potentially induce less quorum sensing)
 
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RagnarLothbrok

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Wonder why no one is talking about the latest results posted in follicle thought
There is some early evidence of regeneration with FUE. If the following weeks confirm it, this is the craziest thing I’ve seen in over a decade of following potential hair loss treatments

I’m even wondering if verteportin would regenerate hair from dermarrolling or dermabrasion
Many people is following it, but sadly this forum became infected with trolls, half people getting locked out of their accs because they cant verify email. The autist c0ck worshiping dude who comments in every thread with 5 accounts and downvotes every comment, and so on.

So naturally people are starting to leave this shitty forum. Hopefully one day the mods put order again because it used to be a great resource.
 

glammetal

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Thats not how follicle neogenesis works. In this trial the follicles taken from the donor were **completely removed** in its whole entirety. Gone. No follicle cells left. No transections. The follicle is literally gone, there is nothing to "rebuild" in that sense, so every new hair sprouted is already a positive gain.

That is what is mindblowing about this trial. A follicle magically can grow out of nowhere. The process involved is called "quorum sensing" where nearby cells can signal to new forming cells which cell it should be. Obviously the fact that before there was a follicle existing there also helps in the whole process.

If a new hair grows that didn't even exist to begin with it is to be celebrated, and there's no scientific evidence that it should contain the exact same amount of hairs as the extracted one. We yet have to see if they will manage to become full terminal though.

Nonetheless, it is very positive news so far only 8 weeks in and esp. considering this proof of concept trial in human is not even the same as was used in mice and pig. (Donor was depleted via skin patch removal and not small FUE holes which could potentially induce less quorum sensing)
"so far only 8 weeks in and esp"Do you refer at the trial that the hair surgeon from Jordan does? Thank you very much
 

RagnarLothbrok

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yeah, the last update is after 8 weeks of initial Verteporfin injection on transplant day.

Mice/pig trial started showing noticeable results after 4 months.
 

glammetal

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If only the Longaker Lab could proceed to clinical trials...That would be the real deal......
 
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