Verteporfin drug induced scarless healing with new hair follicles on mice. This new founding can be really big
- Thread starter stressftw
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Correct
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Found this video that is related. Can give an idea on how this would work in theory.
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OK so I read through the study. It's a dud guys. The depth of the wounds are .07 inches ~ 1.75mm and an FUT is much deeper as terminal hairs tend to go about 7mm deep. So I doubt this is going to regenerate terminal hairs but possibly velius hairs? Either way it isn't an answer to unlimited donor supply.
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But can it recover at the level of subcutaneous tissue? So far they only proven recovery of sweat glands and reduction of scars on the surface. But regenerating terminal hairs? I doubt it.
This is a diagram of a terminal hair follicle. The hair lies at the top layer of subcutaneous tissue which is about 4mm deep.
That's what guys on these forums tend to miss about skin-healing progress. Regrowing skin tissue is not the same thing as creating or restoring terminal hairs.
If you lose an arm, covering the stump wound with skin is one thing. Regrowing the lost arm is something else.
If you lose an arm, covering the stump wound with skin is one thing. Regrowing the lost arm is something else.
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Don't get me wrong, I do hope this helps with scarring because that's the biggest reason why Norwood 3 candidates avoid transplants because they know down the road you will have to shave anyway but have scars.
If this recreated sweat glands and prevented the noticeable surface lumps from scarring then I probably would get a hair transplants down the road.
Guys this video is publiclshed on September of 2020.They they mention that they plan to finish their phase 3 trial in about a year. So by now they should finish their phase 3 trial. However when I go at their site about this treatment it show "error 404".Does anybody know anything more about the time this will be released?
But the study with pigs are related to recover of hair follicles too. Not just the regrowth skin tissue.
Can you link where is was said with the study, please?
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Disrupting biological sensors of force promotes tissue regeneration in large organisms - Nature Communications
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.
www.nature.com
Search for 0.07 and you'll find the part I'm referring to.
Vellus hairs are shallow while terminal hairs are deep, but the thing is normal hairs essentially goes from almost vellus to the deep large sexy hairs we all want so much. As long as regenerated hairs are of the normal type I don't see a reason for new hairs not being able to grow down.
Also there's proximity effects so the depth of the wound doesn't hinder changes deeper down.
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Even if that were true, these FUT wounds can't just be left alone for infection like in these trials, especially since the wound is close to the brain.
True that would be a problem. However if these drugs work for FUE wounds or even the tiny microneedling ones we could have something very nice.
Proof is in the pudding as they say...
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Guys regarding fibrosis, isn't dmso supposed to be effective for reducing/inhibiting it?
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Are any scar removal doctors using this yet?
FollicleThought shared new information about the hair transplant surgeon who uses verteporfin in his patients:
folliclethought.com
Dr. Taleb Barghouthi of the Vertex Hair Clinic located in Jordan has begun an experimental pilot study injecting verteporfin into FUE donor extraction sites to observe the potential of decreased scarring and donor regeneration (though regeneration is more of a long shot at this point). To clarify, this is not within the typical standards of care offered by Dr. Barghouthi and is not currently offered as a service. All patients involved have been ethically informed and consented to the study design. Verteporfin is an FDA-approved medication being investigated for an off-label use. Below are a few images from the first patient treated in the study.
The Best Of Hair Transplants 2022 - Follicle Thought
This article contains a wealth of information on hair transplant surgery, photographic examples of hair transplant results, and practical guidance on how to make the right decisions when considering a hair transplant surgeon. Hair Transplant Surgery – 2022 Hair transplants have become an...
folliclethought.com
Dr. Taleb Barghouthi of the Vertex Hair Clinic located in Jordan has begun an experimental pilot study injecting verteporfin into FUE donor extraction sites to observe the potential of decreased scarring and donor regeneration (though regeneration is more of a long shot at this point). To clarify, this is not within the typical standards of care offered by Dr. Barghouthi and is not currently offered as a service. All patients involved have been ethically informed and consented to the study design. Verteporfin is an FDA-approved medication being investigated for an off-label use. Below are a few images from the first patient treated in the study.
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It looks like it helps with the scar tissue. To me that is a big deal.FollicleThought shared new information about the hair transplant surgeon who uses verteporfin in his patients:
The Best Of Hair Transplants 2022 - Follicle Thought
This article contains a wealth of information on hair transplant surgery, photographic examples of hair transplant results, and practical guidance on how to make the right decisions when considering a hair transplant surgeon. Hair Transplant Surgery – 2022 Hair transplants have become an...
Dr. Taleb Barghouthi of the Vertex Hair Clinic located in Jordan has begun an experimental pilot study injecting verteporfin into FUE donor extraction sites to observe the potential of decreased scarring and donor regeneration (though regeneration is more of a long shot at this point). To clarify, this is not within the typical standards of care offered by Dr. Barghouthi and is not currently offered as a service. All patients involved have been ethically informed and consented to the study design. Verteporfin is an FDA-approved medication being investigated for an off-label use. Below are a few images from the first patient treated in the study.
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this seems amazing for hairline reduction surgery, which is arguably the best way to have thickest natural hairline ever without using *ANY* donor graft at all. The problem is it sucks because of the visible scar... but... if Verteporfin produces a scarless incision it would become extremely valuable option to consider. It can save you at least 3-4K grafts and is way cheaper than hair transplant. Results are immediate.FollicleThought shared new information about the hair transplant surgeon who uses verteporfin in his patients:
The Best Of Hair Transplants 2022 - Follicle Thought
This article contains a wealth of information on hair transplant surgery, photographic examples of hair transplant results, and practical guidance on how to make the right decisions when considering a hair transplant surgeon. Hair Transplant Surgery – 2022 Hair transplants have become an...
Dr. Taleb Barghouthi of the Vertex Hair Clinic located in Jordan has begun an experimental pilot study injecting verteporfin into FUE donor extraction sites to observe the potential of decreased scarring and donor regeneration (though regeneration is more of a long shot at this point). To clarify, this is not within the typical standards of care offered by Dr. Barghouthi and is not currently offered as a service. All patients involved have been ethically informed and consented to the study design. Verteporfin is an FDA-approved medication being investigated for an off-label use. Below are a few images from the first patient treated in the study.
some examples of forehead reduction incisions