why is it over for DUPA? does an anti androgen + hair transplant not work if you have diffused hair loss?
Why there will NEVER be a cure for baldness
- Thread starter Hairful
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Retrogade reduces donor area from sides, that’s what he means.
whatintheworld
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Your donor will also be diffused and won't grow like normal hair. Effectively your donor is miniaturized just like your recipient area, but it doesn't fall out completely like the top.
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You think an anti androgen is even necessary? Donor (if taken from the safe zone using strip) should be fairly DHT resistant. I’ve never seen a completely bald guy. Everyone has decent hair over their occipital.
whatintheworld
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Yes, there is some scientific evidence/research to suggest the donor area accepts certain characteristics of the recipient area when it is transplanted.
Most men will probably be fine and maybe suffer 5-10% loss as senile alopecia progresses as they age, but the higher Norwood you are and the less "robust" your donor looks, the more susceptible you may be to your transplanted hair thinning out over the long run (5-10 years +).
Link?
Doesn't work for NW7 area diffusers, which is most aggressive balders.
whatintheworld
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https://www.jcasonline.com/article....;issue=4;spage=292;epage=297;aulast=Kumaresan
| Abstract | |
Here are some more examples:
https://pubmed.ncbi.nlm.nih.gov/16931898/
Abstract
Pathogenetic mechanisms in androgenetic alopecia are not yet fully understood; however, it is commonly accepted that androgens like testosterone (T) and 5alpha-dihydrotestosterone (5alpha-DHT) inhibit hair follicle activity with early induction of the catagen. Thus, we investigated the influence of T and 5alpha-DHT on proliferation, cell death and bcl-2/bax expression in cultured dermal papilla cells (DPC) from nonbalding scalp regions of healthy volunteers. T and 5alpha-DHT induced apoptosis in DPC in a dose-dependent and time-related manner; in addition a necrotic effect due to T at 10(-5) M was found. Interestingly, bcl-2 protein expression was decreased in T- and 5alpha-DHT-treated cells, leading to an increase in the bax/bcl-2 ratio. In addition, T and 5alpha-DHT induced proteolytic cleavage of caspase 8 and inhibited proliferation of DPC at 10(-5) M. High concentrations of T and 5alpha-DHT were needed to induce apoptotic effects in DPC. These data suggest that DPC from nonbalding scalp regions do have the capacity to undergo apoptosis, but need a high androgen stimulus. The present study provides an interesting new pathogenetic approach in androgenetic alopecia.Even Dr. Bernstein, a respected surgeon, raises suspicions about it with evidence:
https://www.bernsteinmedical.com/research/donor-dominance-revisited/
whatintheworld
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Like I said, NW7 with DUPA is the exception.
A Norwood 7 with a decent donor can have a good result but only in the hands of the best surgeons, I have seen it in person and on other forums.
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I like both of your arguments
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Don’t lie. Too much tugging on the old lizard made you bald.
If it's not "eating right" and "giving up bad habits", I'd like to hear what exactly you mean by "cure".
I believe that there are factors that make bald genetic people lose hair much earlier than normal. I'm trying to identify that factors and fix them. Sorry but if I don't get the result, I won't post my hypothesis. It's just a waste of your time and I'll get laughed at by members here. I need at least 3 more months to see if I get any process. If I succeed, I'll post everything here.
What are you dying to identify them? Are you funding a twin study?
Bro, I know your stance in this discussion. You believe that Androgenetic Alopecia is purely genetic. I respect you and your knowledge but let's agree to disagree.
- I live in a third-world country. The balding rate in my country rising very fast along with the significant change in lifestyle. To help you imagine, in the year 2000 only the upper class in my country have a TV, now nearly everyone has a smartphone. I strongly believe that there are factors that make people lose hair much earlier than normal. I think you are living in a first-world country, and you can't see that change.
- There's a study that shows identical twins have different balding rates: https://www.researchgate.net/public...igenetic_differences_in_androgenetic_alopecia. In this study they collect information like smoking and alcohol, which is IMO not the real problem.
- I don't have money, and I'm not intelligent. I experiment on myself for years to see if I change this or that, my hair condition improve or not..
Ppl have been testing stuff on themselves to cure hairloss for centuries. Give up. You will risk your health over nothing.
It seems I understand what you mean, I have already asked this question and it is quite complex and ambiguous. In theory, if we remove the aggravating factors, we could probably return some of the lost hair that should not have fallen out according to the “genetic plan” by this point and slow down the course of Androgenetic Alopecia. In practice, this is difficult to achieve, since there can be too many factors that exacerbate baldness, and the vast majority of them are also not fully understood.
@mminh Actually I don't think it's 100% genetic. It's estimated around 80% genetic in multiple studies. I think that men are going bald earlier all over the world, but there isn't any great evidence to support that opinion. Anecdotaly this seems to be happening in my country as well.
Unfortunately due to how long it takes hair to respond to changes, how slowly it grows, how hard it is to accurately notice a difference without proper equipment, and the lack of any control, I don't think you will have much luck finding a link, much less a testable hypothesis. Smoking has a small effect in twin studies, but alcohol does not. I would imagine that increased steroid use contributes, though probably not in the third world. High speed and free internet pornography has an effect imo as well. Stress is another factor. Even if you find all environmental factors and eliminate them you won't reverse your hair loss, you'll only slow it down.
Unfortunately due to how long it takes hair to respond to changes, how slowly it grows, how hard it is to accurately notice a difference without proper equipment, and the lack of any control, I don't think you will have much luck finding a link, much less a testable hypothesis. Smoking has a small effect in twin studies, but alcohol does not. I would imagine that increased steroid use contributes, though probably not in the third world. High speed and free internet pornography has an effect imo as well. Stress is another factor. Even if you find all environmental factors and eliminate them you won't reverse your hair loss, you'll only slow it down.
@Mighty I appreciate that you worry about my health. You are sensible and most likely right. But I won't give up without a fight.
@Feramon1 @pegasus2 : You are correct. It's very difficult, and even more difficult for me due to some personal reason. I've failed for years. This time I have high hope. This is the first time in years I get consistent normal shedding (more than a week now), my scalp is less greasy, less dandruff, and less itchy. Let's see if in 3 months I can regrowth some hair or not.
@Feramon1 @pegasus2 : You are correct. It's very difficult, and even more difficult for me due to some personal reason. I've failed for years. This time I have high hope. This is the first time in years I get consistent normal shedding (more than a week now), my scalp is less greasy, less dandruff, and less itchy. Let's see if in 3 months I can regrowth some hair or not.