end of baldness.they figured it out all.

[DesperateOne]

If youre going to talk about honesty, you should refrain from claiming any projections. You have no idea what is going to happen in the next 15-20 years. Nobody has a clue of what's going to happen with new trials, how long they take, etc. If you're so certain theres nothing going to be a cure for so many years, why even bother being on any hair loss forum?

These are the facts;

- Follica is able to produce follicles at will through wounding along with certain growth factors
- Dr. Roland Lauster already created artificial skin with follicles that grew hair using stem cells
- The recent news of Jahoda's method along with China's recent discovery is the FINAL step in creating complete follicles at will with ALL of its properties (colour, thickness, etc).

Pretty much all of this has happened within the last 4 years.

Let all of this sink in.

So do you personally think follica will probably be a sooner option than this unlimited follicle farming? If so how longer for follica do you think.

 

[hellouser]

So do you personally think follica will probably be a sooner option than this unlimited follicle farming? If so how longer for follica do you think.

I don't know. Your guess is as good as mine. You could take into account exponential growth, but that probably won't matter much as the Phase I, II and III trials have to be based on a specific application of method to use to treat hair loss and the protocol (afaik) cannot change unless you plan on restarting everything all the way from pre-clinical. So, whatever method Follica had years ago is still being ironed out with their Phase II and III trials. Their funding comes from Puretech Ventures. Here's their pipeline which includes Follica;

http://www.puretechventures.com/pipeline.php

As you can see, they're half way through human clinical trials. Now here's the BIG problem with Follica;

Follica has been in clinical trials for at least the last 5 years!

They've only recently finished a series of Phase II trials in Europe:

https://www.clinicaltrialsregister.eu/ctr-search/search?query=follica

I'm not sure if this is Phase IIa or both IIa and IIb, but it could mean they only have one more trial (Phase III) to complete. But given their piss poor track record, how much longer is it going to take them to conduct the LARGEST trial of them all?

Gut feeling? It'll probably be released before a stem cell solution.. when though? None of us knows... you'd have to ask Dr. Cotsarelis and get him to give you an answer that wasn't corporate bullsh*t.

 

[badwabbit]

Controllable production of transplantable adult human high-passage dermal papilla spheroids using 3D Matrigel culture

We have succeeded in culturing human dermal papilla (DP) cells spheroids and developed a three-dimensional Matrigel (basement membrane matrix) culture technique that can enhance and restores DP cells unique characteristics in vitro.

When 10000 DP cells were cultured on the 96 well plates pre-coated with Matrigel for 5 days, both passage 2 and passage 8 DP cells formed spheroidal microtissues with a diameter of 150-250 μm in an aggregative and proliferative manner. We transferred and re-cultured these DP spheroids onto commercial plates. Cells within DP spheres could disaggregate and migrate out, which was similar to primary DP. Moreover, we examined the expression of several genes and proteins associated with hair follicle inductivity of DP cells, such as NCAM, Versican and α-SMA, and confirmed that their expression level was elevated in the spheres compared with the dissociated DP cells. To examine hair-inducing ability of DP spheres, hair germinal matrix cells and DP spheres were mixed and cultured on Matrigel. Unlike the dissociated DP cells and hair germinal matrix cells co-cultured in two dimensions, hair germinal matrix cells can differentiate into hair-like fibers under the induction of the DP spheres made from the high passage cells (passage 8) in vitro.

We are the first to show that passage 3 human hair germinal matrix cells differentiate into hair-like fiber in the presence of human DP spheroids.

These results suggest that three-dimensional Matrigel culture technique is an ideal culture model for forming DP spheroids and that sphere formation partially models the intact DP, resulting in hair induction, even by high passage DP cells.

http://online.liebertpub.com/doi/abs....TEA.2013.0547

so just please do trials in japan fast track we need the cure. thank you. baldness go to hell now

although I am excited to know that they figured out a way to end baldness, I didn't understand a single thing written here 9honestly speaking). maybe there is a more non-technical explanation they can share so (non medical) people can understand it more.

 

[DesperateOne]

All I know is that this situation is unreal. Absolutely nothing can be done, I feel as if I have cancer with no cure, maybe that's how they really feel.

We can't live normal lifes and nothing close is coming. I am going to have to read up on quantum consciousness and see if I can get my hair back that way. I better I have a better shot there than this lol.

 

[hellouser]

And all of things needs 15-20 years to be aviable to the mass public ( if they will).

FALSE.

The average length of time thats required for a new drug to pass even the most ridiculous set of regulations like with the FDA is 15-17 years. Follica is well into their trials. Are you STILL going to make the same claim?

We didnt heard nothing from Roland Lauster last 2-3 years. Maybe he just realise something that creating hair is not too easy process.

Maybe? What do you mean maybe? You have no evidence to support a maybe, lol. He already created hair anyway. MAYBE, like many others, he does'nt give a sh*t to help balding men?

Every second company lost in phase2 trials. Why? Because just they realise that they dont have good results.

FALSE.

RU58841, NEOSH both showed good results with a topical solution. Aderans showed marginal results but better results than finasteride, which already is a monumental success considering it performed better than all the best GARBAGE products we have today, COMBINED.

We are very far from using stem cells,

FALSE.

We're already there. Did you not read anything from the news posted in this thread? Did you not hear about Jahoda's work, or Tsuji Labs' work?

because we still dont know how to fix puzzle.

FALSE.

Thats exactly what the last piece to the puzzle was with the news from China.

It will need 4-5 years to proove if these metod work.

FALSE.

They have all the pieces, they could do a trials on some foreskin NOW like Dr. Jahoda did with his previous findings as well as the findings from China. You don't need 5 years to see if it works. You need about 1 hair growth cycle to see if it works, so no more than 4 months because you have to take into consideration how long it takes to create the follicles, how long it takes for the follicle to grow, how long it takes for hair to grow, then for the hair to sprout from the skin and then see how long it takes for it to grow to a cosmetically significant length (hair grows approx 1cm per month).

Where are the trials, where is the safety, where are the color, angle, cycles and lot of other things.

Trials and safety will come later, this is guaranteed, lol. Colour, angle etc. was the part that China solved. Dr. Jahoda is already able to create hair but without its properties, which China solved. So.... all the pieces have been solved.

We still dont know if hair can grown normal in cycles.

Finally, some truth!

Yes, it will take trials to see if the follicle will grow hair in regular cycles and last for years to come.

 

[hellouser]

Dont be silly! Every scientis want to be the one who will cure the baldness and be HISTORY just like Nikola Tesla is and many more. Maybe he just cant cure the baldness!

Yeah? So where's Dr. Lauster? Dude showed us he created skin with follicles and then vanished like a fart in the wind. Doesn't seem like he was all that interested...

And do we have products from their companies? No, right? And why? You think everything is about FDA? No, and all those companies lies.

You'd have to know the history, parent company that was working on NEOSH got bought out by another company and the whole project was shelved. ARI had its funding pulled by Aderans and decided it'd be more profitable to sell wigs (guys at the top are sh*theads for doing this), but also they didnt show the kind of results Aderans would have wanted to see anyway. RU was shelved due to costs for Phase III. Nobody lied.

Yes, and they alredy said that their product is 10-15 years from market and who knows if will go out on market.

No, Tsuji Labs never stated '10-15 years for a product'. They're a research lab, not a for-profit biotech.

Lot of scientist just lies to get publicity. We dont know if they can culture DP cells. When i will see proof then i will say it works. Till then i am not saying anything. Just like the cancer cure. We hear that every day and that the scientist are really close.

In best scenario we are at least 15 years from real treatment.

I give up. :doh:

 

[benjt]

simple answer -- the crap doesn't work and they know it...

Your level of stupidity is simply marvelous.

• We have one treatment with no backing in science whatsoever and its efficacy for hairloss treatment only claimed in psychic readings, the violet ray, which you are a profound defender of because "there MIGHT be something to it".
• Then we have a treatment by RepliCel which shows an 11.8% increase in hair density after 6 months and the data gained through clinical trials. RepliCel has a contract with Shiseido, the fourth largest cosmetics and hair care company in the world which gave major funding to RepliCel and assures Shiseodi has exclusive market rights in SEA. and through which Shiseido paid millions to RepliCel, implicating that in the opinion of Shiseido, this product does work. But obviously, in your understanding, "the crap doesn't work", even though we have data that actually shows it works.

@hellouser: As I had said earlier in this thread, their own schedule says market availability in 2018 and 2019. I could not find any claims that their product would be available on the market in 2015. And while the FDA might be taking its time, Shiseido - the ones who will be effectively offering the treatment - said themselves it will be available in 2018 or 2019 in SEA, so you could go to Japan to receive the treatment. It is likely that this deadline is part of the legal agreement between Shiseido and RepliCel, i.e. if RepliCel don't deliver on time they might have to pay penalties. If they didn't expect themselves to be 100% done by the time they would not agree on such a contract.

 

[Sparky4444]

Your level of stupidity is simply marvelous.

• We have one treatment with no backing in science whatsoever and its efficacy for hairloss treatment only claimed in psychic readings, the violet ray, which you are a profound defender of because "there MIGHT be something to it".
• Then we have a treatment by RepliCel which shows an 11.8% increase in hair density after 6 months and the data gained through clinical trials. RepliCel has a contract with Shiseido, the fourth largest cosmetics and hair care company in the world which gave major funding to RepliCel and assures Shiseodi has exclusive market rights in SEA. and through which Shiseido paid millions to RepliCel, implicating that in the opinion of Shiseido, this product does work. But obviously, in your understanding, "the crap doesn't work", even though we have data that actually shows it works.

@hellouser: As I had said earlier in this thread, their own schedule says market availability in 2018 and 2019. I could not find any claims that their product would be available on the market in 2015. And while the FDA might be taking its time, Shiseido - the ones who will be effectively offering the treatment - said themselves it will be available in 2018 or 2019 in SEA, so you could go to Japan to receive the treatment. It is likely that this deadline is part of the legal agreement between Shiseido and RepliCel, i.e. if RepliCel don't deliver on time they might have to pay penalties. If they didn't expect themselves to be 100% done by the time they would not agree on such a contract.

Who's level of stupidity is marvelous??? I'll spend thousands more, on top of the thousands for the treatment, to go to Japan to get a treatment that will barely give me a cosmetic difference...plus I have to keep going back, it's not a one-time shot...PLUS 2018 or 2019...screw them....they've been at this a long time ---

....if this was a great breakthrough, they wouldn't be going through a cosmetics company for funding and marketing....they wouldn't have to...this is all smoke-screen BS for something that won't be THE BREAKTHROUGH...or any subset of a BREAKTHROUGH

...if it smells like a rat, looks like a rat and sounds like a rat, it most likely is a rat...Much like your level of intelligence which would be giving the rat too much credit....

...gawd your obtuse...get out of your house and into the real-world a bit, might do you some good

 

[benjt]

....if this was a great breakthrough, they wouldn't be going through a cosmetics company for funding and marketing....

Why? RepliCel is an R&D company, they need somebody for distribution and application. Why would they not go through Shiseido?

...if it smells like a rat, looks like a rat and sounds like a rat, it most likely is a rat...

You are the one who said "we have to try everything that MIGHT work". Now there is something that actually has data proving it works, and you say "it smells like a rat", unlike the violet ray which you defend, which has no data to back it up? The violet ray, by the way, is something that smells like rat. Its advocates just say "yeah, this works" without giving any proof.

You really could use some common sense. And an aggression therapy.

 

[Sparky4444]

You are the one who said "we have to try everything that MIGHT work". Now there is something that actually has data proving it works, and you say "it smells like a rat", unlike the violet ray which you defend, which has no data to back it up? The violet ray, by the way, is something that smells like rat. Its advocates just say "yeah, this works" without giving any proof.

You really could use some common sense. And an aggression therapy.

...where did I ever say "we have to try everything that MIGHT work"??? Part of my aggression towards you is about you putting words in my mouth and twisting my intent...I am done with the VR thread -- and if you want to bring the fight to this thread, I'll PM the Moderator and move to have you banned....You're comparing spending thousands on a treatment program (5 years from now, mind you) - and having to go to Japan in the process - versus looking for an in-house way to help stimulate the DR process so I can improve my vertex coverage to compliment a major investment in frontal hair transplant????

..you're nuts..and you've been corrected by Hellouser who is exhibiting more insight into ACell than you've shown...you have a real problem dude -- you are a potential socio-path who needs to be "right" for you and your ego to survive....you transgress once more about the VR thread outside of it, and I'm going to the Moderator...

 

[benjt]

...where did I ever say "we have to try everything that MIGHT work"???

In the VR thread, but the wording was indeed more "we should not dismiss anything that MIGHT work". Should I look it up for you?

Again, you evaded the crucial questions:

• Why does RepliCel "smell of rat", if data shows a 12% increase in hair density after 6 months?
• Why would they not go through Shiseido, as they are only an R&D company without any own distribution infrastructure?

and you've been corrected by Hellouser who is exhibiting more insight into ACell than you've shown...

I don't know if you noticed, but we're talking about RepliCel here, not ACell. And where have I been corrected by Hellouser again?

you transgress once more about the VR thread outside of it, and I'm going to the Moderator...

Oh, please do. I mean, I was not the one who called others Nazis, compared them to Hitler, told them to suck c***, and so on.

Please note that sentences ending in a "?" are questions. It would show utmost kindness and adherence to basic conversational rules if you actually answered them, instead of posting even more insults.

 

[peacemaker]

Well my money is on Follica. I feel closer to them for some reason. I also like Cotsarelis. He seems like a stand up guy. He seems to know what he is talking about. Also, even the most basic version of their treatment, a.k.a wounding, seems to be working for me. I love my new thin hairs that are not vellus, but not yet terminal. And I am only on my 4th DRing session. If the company finds the right chemical to boost the growth and inhibit the growth halting proteins, which I am sure they did and are testing right now, they will win this game and kick ***!

 

[benjt]

The problem with Follica is that market availability will likely take longer for them than for RepliCel. It's certain that RepliCel will be available some time in the first half of 2019 in SEA. It's quite unfortunate because that's still quite a while, but I couldn't find any dates for Follica - if someone has them, please post.

 

[Sparky4444]

Please note that sentences ending in a "?" are questions. It would show utmost kindness and adherence to basic conversational rules if you actually answered them, instead of posting even more insults.

And if I felt like answering to you I would answer the question...unfortunately, you just have no value to me and I owe you no respect and no accountability...lol...you really are a socio-path...

 

[benjt]

As expected, just a bad excuse for not giving answers that you don't have.

You know, when people make claims they ought to base them on something. You just make empty statements as you seem fit, no matter if they are lies or not. You refuse all responsibility for your own statements as you don't see the necessity to explain what they are based on. That is claiming something "with ABSOLUTION". No reasons given - "it just is because I say so and I don't have to explain myself", that is your approach.

 

[Sparky4444]

:wave: ....thank you, thank you very much -- I'll be here all week..remember to tip your waitresses well..

:tongue:

- - - Updated - - -

...keep in mind some of those were for karenkaren...so don't get to cocky there bend-over

 

[benjt]

Sparx4444, I don't care one bit about your insults. Insults are what people who don't have arguments have to resort to. If you had arguments, you would not need to insult me.

What I do care about, though, is you trying to discredit my posts. We are trying to discuss research here and you are sabotaging the discussion, as you just admitted.

 

[hellouser]

Can you guys get a room? You're derailing the thread again.

 

[benjt]

Getting back on the topic from before derailing: Do you have any timeline/schedule information for Follica? I couldn't find anything.

 

[hellouser]

Getting back on the topic from before derailing: Do you have any timeline/schedule information for Follica? I couldn't find anything.

Just this:

http://www.puretechventures.com/pipeline.php

Apparently Phase II trials are complete in EU (unsure if theyre IIa or IIb or if there were ever two sets of Phase II trials like Histogen's IIa/IIb)