Italian Hair Loss Lotion To Hit The Market In 2016

[Dus]

I think its great that their reply changed! It means they are having to respond differently because they feel the pressure of people wanting this now. They need to know there is a demand for this product. Hell keep emailing every week.
Whats their email address, ill send one today as well!

You sound like a complete retard.

 

[keep]

I think it's better for us to wait... rather than spamming someone's inbox, but it is your call.

 

[pegasus2]

I think it's better for us to wait... rather than spamming someone's inbox, but it is your call.

It's not going to affect when it's released. They already know there is a huge market for hair loss treatments, so emailing them isn't going to make them speed things up, even if they could. They aren't going to slow things down just out of spite for spamming them either. It could make them less communicative though. I'm not particularly interested in this treatment myself, although I might give it a shot when it's available, if it's reasonably priced. For those of you who are though, it would be best if you picked one person, preferably someone fluent in Italian, as a liaison between Fidia and the forum. They would be more likely to give useful information to one person than to dozens of people emailing the same questions. That will make them shut down communication, and give canned responses with no useful information.

 

[Swoop]

So much for hair loss not being a sign of aging.

Speaking of that.. Oxidative stress might be primary involved in Androgenetic Alopecia. Things seem to be pointing towards that..

Recent study for example; "Comparative Transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression: Whole transcriptome discovery study identifies altered oxidation-reduction state in hair follicles of androgenetic alopecia patients" http://www.ncbi.nlm.nih.gov/pubmed/27239811

If this turns out to be true then it's pretty bad news.

 

[Eren]

Cellular and developmental aspects of androgenetic alopecia, Jahoda - http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00666.x/pdf

Yes the pattern is interesting. But isn't it interesting too how hair grows in infants? It's pretty much the other way around. The hair at the frontoparietal and frontal regions sometimes grows in last. Also they tend to have 1 follicular units first which progress later to 2-3-4. That's why they have silky hair in the beginning and not much coverage. In Androgenetic Alopecia it's exactly the other way around very often. Progresses to 1 follicular units, and hair loss often starts and the frontoparietal and frontal regions.

What I find interesting also is the following observation;

Eunuchs retain their hair when castrated prepubertally obviously. Now you take one older eunuch and one young eunuch. Both are NW1's. You inject them both with androgens. The older eunuchs tend to lose their hair extremely rapidly while the younger way more slowly. Why? Cells weaker with old age and more susceptible to stress/damage? I don't know.

It has to do with something called 'gene expression.' That's why almost no one has male pattern baldness at 14 while I, for example, had more than enough DHT to go bald at that age (beard growth AF at that age). The DHT receptors should be activated before DHT can destroy your hair. That's why some start to lose it at 27 while others already start in their late teens, receptor activation.

Here is something from Bernstein's site: 'Complicating the issue further, just having the genes for baldness in your genetic makeup, does not guarantee that the trait will manifest. The baldness genes need to be “turned on” or “expressed” in order for androgenetic alopecia to be apparent. Gene expression is related to a number of factors, the major ones being hormones and age, although stress and other factors can contribute to hair loss in some individuals.'

Thus, if that eunuch's receptors aren't activated, nothing will happen. Also, not every eunuch has DHT sensitive hairs to begin with . It could very well be that he was castrated but would not have gone bald even if he would not have been castrated.

http://www.bernsteinmedical.com/hair-loss/men/causes/

 

[Afro_Vacancy]

Speaking of that.. Oxidative stress might be primary involved in Androgenetic Alopecia. Things seem to be pointing towards that..

Recent study for example; "Comparative Transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression: Whole transcriptome discovery study identifies altered oxidation-reduction state in hair follicles of androgenetic alopecia patients" http://www.ncbi.nlm.nih.gov/pubmed/27239811

If this turns out to be true then it's pretty bad news.

Why would that be bad news?

 

[abcdefg]

What I think is interesting is that they say male pattern baldness is directly caused by aging. Is that true? I have seen women at like 60+ years old that have Norwood 1 almost teenage hair density still. Its odd to me if its aging some women are not at all affected, but if you look at older men like 60+ its even more rare. Hormones are the big difference between men and women and accounts for old age hair loss too. I still think male pattern baldness is almost 99 percent completely androgen driven. I still have yet to see any evidence even remotely as powerful as hamilton showing us that castration 100 percent prevents male pattern baldness. I mean that is just amazing.
Castrated men still age, have oxidative stress, and all those other factors they say factor into male pattern baldness yet they still dont go bald as you would expect. It has to be androgen driven or those other factors would cause male pattern baldness to start again.

 

[Eren]

What I think is interesting is that they say male pattern baldness is directly caused by aging. Is that true? I have seen women at like 60+ years old that have Norwood 1 almost teenage hair density still. Its odd to me if its aging some women are not at all affected, but if you look at older men like 60+ its even more rare. Hormones are the big difference between men and women and accounts for old age hair loss too. I still think male pattern baldness is almost 99 percent completely androgen driven. I still have yet to see any evidence even remotely as powerful as hamilton showing us that castration 100 percent prevents male pattern baldness. I mean that is just amazing.
Castrated men still age, have oxidative stress, and all those other factors they say factor into male pattern baldness yet they still dont go bald as you would expect. It has to be androgen driven or those other factors would cause male pattern baldness to start again.

Hair loss is age related in the sense that more and more people tend to lose hair over time. At the age of 20 only 20% deals with it and at age 50 that is already 50%.

male pattern baldness (i.e. sensitivity of the hair follicles to DHT) is not age related as far as I know.

Btw, even if you have ZERO male pattern baldness genes, you can still lose hair. I mean, in the end if one hair follicle could produce infinite amount of hairs no one would go bald anyway. After the age of 60 hair loss isn't necessarily androgen driven. Even eunuchs can have hair loss after those ages!

There was that Chinese eunuch who wrote a book and he had a NW3 hairline (castrated at the age of 7 to 8).

 

[Roberto_72]

Hair loss is age related in the sense that more and more people tend to lose hair over time. At the age of 20 only 20% deals with it and at age 50 that is already 50%.

male pattern baldness (i.e. sensitivity of the hair follicles to DHT) is not age related as far as I know.

Btw, even if you have ZERO male pattern baldness genes, you can still lose hair. I mean, in the end if one hair follicle could produce infinite amount of hairs no one would go bald anyway. After the age of 60 hair loss isn't necessarily androgen driven. Even eunuchs can have hair loss after those ages!

There was that Chinese eunuch who wrote a book and he had a NW3 hairline (castrated at the age of 7 to 8).

Could it be that older people have had more chances for the male pattern baldness to be triggered? As with cancer: at 80s, the chances you might have cancer are incredibly higher than at 20, because your body is weaker AND because in your life you have been exposed to more and more cancer triggers.

Either that or, simply put, baldness is one of the signs that the body conveys to the outside world making it known that you are aging and your reproductive role should change. A bit like grey hair, although grey hair is much more common.

 

[Follisket]

Well, set fire to the curtains and wait for your house to burn down. Of course the damage will correlate with time just as baldness does with age; doesn't mean it's the cause or a natural part of it. Without a flame there is no fire, no matter how much time passes.

Besides, as long as there are 80-yo fullheads walking around and <30-yos going bald, equating baldness with aging is absolute madness.

A bit like grey hair, although grey hair is much more common.

Not to mention far less repusive and a heckuva lot easier to fix if you want to.

 

[Swoop]

@Eren,

Thanks, I was more implying to the speed of miniaturization. Anyway it's probably a combination of what you mention and that cells get weaker with age I guess. Do you have a link or some more information of that eunuch case by the way?

Why would that be bad news?

Cause it leads to bad things... Like senescence, basically a irreversible state of cell cycle arrest. Or fibrosis, which leads to permanent destruction of hair follicle structures (which by the way has been shown in studies in some subjects).

What I think is interesting is that they say male pattern baldness is directly caused by aging. Is that true?

You mean in the study I posted? No I haven't read that. Like you know androgens are still a prerequisite for Androgenetic Alopecia to occur. No androgens = no Androgenetic Alopecia, same could be said for the androgen receptor.

However to purely simplify it, look at it this way. Androgens > AR > Oxidative stress.

 

[Eren]

@Eren,

Thanks, I was more implying to the speed of miniaturization. Anyway it's probably a combination of what you mention and that cells get weaker with age I guess. Do you have a link or some more information of that eunuch case by the way?

His name was Sun Yaoting. From wikipedia

"Sun Yaoting (Traditional Chinese: 孫耀庭, Simplified Chinese: 孙耀庭, Hanyu Pinyin: Sūn Yàotíng, Wade-Giles: Sun Yao-t'ing; September 29, 1902 – December 17, 1996) was the last surviving imperial eunuch of Chinese history. He was castrated at the age of eight by his father[SUP][1][/SUP] with a single swoop of a razor, mere months before the final emperor was deposed."

Here is his photo at the age of 94 taken in 1996

Harsh history though.

Back to hair loss again, as you can see he did lose hair, is receded despite being castrated at the age of eight (he didn't even have a dick anymore, inhumane this).

 

[Solomon]

@Swoop

Do castrated men have high levels of PGD2?

 

[Swoop]

@Eren,

Damn that's cruel man. Indeed he has some recession it seems but the rest of his hair seems in quite good shape despite his old age.

@Swoop

Do castrated men have high levels of PGD2?

Don't know man, no data on that. But my guess is, no. Check by the way; http://www.cassiopea.com/activities/product-pipeline/breezula.aspx

Breezula™ acts at cutaneous level on the scalp by blocking DHT interaction with the specific hair-follicle androgen receptors. Breezula™ also reduces the skin’s production of prostaglandin D2, a hormone-like compound that, in elevated levels, can inhibit hair growth.

Btw going bit off-topic here, sorry for that unk:.

 

[Mach]

Speaking of that.. Oxidative stress might be primary involved in Androgenetic Alopecia. Things seem to be pointing towards that..

Recent study for example; "Comparative Transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression: Whole transcriptome discovery study identifies altered oxidation-reduction state in hair follicles of androgenetic alopecia patients" http://www.ncbi.nlm.nih.gov/pubmed/27239811

If this turns out to be true then it's pretty bad news.

Doesn't lllt reduce Oxidative stress?
Sorry if this was mentioned earlier.

 

[abcdefg]

Its interesting because dont castrated men still have some T + DHT even if the levels are significantly lowered? What if his sensitivity was just higher and the little androgens he had left were able to still carry on the process. We know as you age your sensitivity seems to keep increasing

 

[resu]

@Eren,

Damn that's cruel man. Indeed he has some recession it seems but the rest of his hair seems in quite good shape despite his old age.



Don't know man, no data on that. But my guess is, no. Check by the way; http://www.cassiopea.com/activities/product-pipeline/breezula.aspx



Btw going bit off-topic here, sorry for that unk:.

Too bad we'll have to wait till 2020 or later until we can have it in our scalps.

 

[Swoop]

Too bad we'll have to wait till 2020 or later until we can have it in our scalps.

Yeah timeline is a bit of a bummer. Ridiculous how long all these clinical trials take, all the red-tape etc.

Btw interesting video that I came across about s-equol (turn on the subtitle)!

[video=youtube;Y-oNnHAc_wI]https://www.youtube.com/watch?v=Y-oNnHAc_wI[/video]

 

[ReasonableMan]

Too bad we'll have to wait till 2020 or later until we can have it in our scalps.

Wait - wasn't this supposed to be released on a much shorter timeline? Where is 2020 from?

edit: sorry, didn't realise this was regarding a different product.

 

[resu]

Wait - wasn't this supposed to be released on a much shorter timeline? Where is 2020 from?

edit: sorry, didn't realise this was regarding a different product.

The acne version was to be released in 2018 haven't checked their timeline but wouldn't be surprised if that also got delayed.