Italian Hair Loss Lotion To Hit The Market In 2016
- Thread starter paleocapa89
- Start date
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That day must come.
Yeah believe me I hope it does. Id rather never touch finasteride. I told myself that for the last 10 years since there were so many articles on coming cures in the next 5 years.
There is no way getting around changing hormones even s-equol would do something similar, but if it can done safer or not altering other things like neurosteroids that would be a good alternative to propecia. Topical will always be safer then internal
This. There have been more promising treatments than this in the past that didn't work, or were dropped for other reasons.
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Fidia emailed me and said news will be posted after summer holiday. I honestly beileve this could be something for people that have been losing hair for less than 10 years
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When is summer holiday in Italy?
Whole summer?
;-)
Whole summer?
;-)
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Lol she clarified "U.S. Summer"
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So any hair lost in the last 10 years could be regained? Rejoice I hope you are right!!
I hear a lot about a so called "30 month window". How is Brotzu able to get around those claims?
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Brotzu had said a while back that the lotion restores 5 years.
That was an anecdotal average, clearly.
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All indications positive.
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Thing is this would work on a temples but surely if you're diffuse thinning and have hair in places where you still want to apply lotion it must be a pain to apply it?
I hope this isn't going to extortionately priced aswell.
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As far as I can recall they haven't said anything about crown vs temples vs hairline vs diffuse thinning.
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Review post.
The three ingrediants in this formulation are S-equol, DGLA, and L-Carnitine. In the interview translated by google here:
https://www.hairlosstalk.com/intera...the-market-in-2016.96791/page-34#post-1338585
Brotzu says that:
- S-equol accounts for 80/180 ~ 45% of the total effectiveness of the formulation.
- DGLA, a precursor to PGE1, is used instead of PGE1 to be classified as a cosmetic and not a pharmaceutical. He says it works just as well or better.
- L-Carnitine helps with the beta-oxidation of lipid chains (I don't know what that means).
- There is a trial of 60 people for Androgenetic Alopecia run by Fidia, he himself is running his own trial of 18 people for alopecia areata, which is the area that interests him more.
So overall I'm expecting something similar to a topical finasteride+minodixil, but with a different side effect profile.
S-equol is better than finasteride as it blocks DHT rather than blocking the precursor 5-alpha reductase. We know that tons of Asia has tons of equol in their blood and they don't have brain fog and erectile dysfunction. That is not just because 50% of Asians can convert soy to equol (compared to 30% of whites), but also because unlike whites Asians actually eat a lot of soy. White people who can produce equol but only eat soy twice a month are effectively not producing equol for all intents and purposes.
I suspect DGLA will be similar to minoxidil, as it's a precursor to PGE1, and I've seen arguments that minoxidil is linked to PGE1. Carnitine is doing something else.
The cationic liposomes are a delivery system they're bragging about.
What I don't know:
1) A possible side effect of this drug might be priapism -- the opposite of erectile dysfunction. I wish someone who knows more would look into it. I infer this because PGE1 is a primary treatment of erectile dysfunction, and l-carnitine is an off-label treatment for erectile dysfunction:
Carnitine:
http://www.life-enhancement.com/mag...itines-better-than-testosterone-for-impotence
Carnitines—Better Than
Testosterone for Impotence
Propionyl and acetyl carnitine derivatives beat
sex hormone at its own game and enhance v****’s benefits
By Will Block
PGE1:
https://en.wikipedia.org/wiki/Prostaglandin_E1
Prostaglandin E1 (PGE1) is a prostaglandin.
The synthetic variant is known pharmaceutically as alprostadil.[1] It is a drug used in the continuous treatment of erectile dysfunction[2] and has vasodilatory properties.
2) I have seen no information on the cost of lotion, nor of whether the trial is for 6 months or 12 months (which will set the release date).
3) What does beta oxidation of lipid chains means?
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Wouldn't the "restore 5 years hairloss" that I'm hearing be subjective to the individual? Those with more aggressive male pattern baldness would lose 1-2 Norwood in that time compared to someone with less who might lose minimal amounts of hair in 5 years, I would expect them to both regrow the same amount of hair?
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http://www.unica.it/pub/7/show.jsp?id=30328&iso=1021&is=7
Interview number 9
Interview number 9
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Translation courtesy of google:
9 - L'Unione Sarda
Health (page 36 - CA Edition)
discoveries
Alopecia: you can heal?
The trial of John Brotzu
A small light came on, by chance, on a disease for which there is still no cure certain outcome: alopecia. The hope is still in test tube: a lotion which up to now has given excellent results, but still on a limited sample. The solution developed by Professor John Brotzu, son of art and vascular surgeon of repute, (the father is entitled to Cagliari hospital), it was a pleasant hiccup as part of a search for treatment of diabetic microangiopathy, which has gone on for almost 15 years. It is an intravenous infusion that proved invaluable for hair loss. The discovery signed by Professor Brotzu, by his son Joseph and by three researchers at the University of Cagliari (Fadda Anna Maria, Francesca Marongiu and Maria Letizia is missing), it has already been published in the magazine The Dermatologist specializing in the number of March 2015.
But what does alopecia with diabetes?
"We were working on a drug for the treatment vascular insufficiency in patients with diabetes: the disease begins with the fall of the hair in the legs, then the taste buds, and in the worst cases the limbs. The solution that we administer intravenously is quite difficult to prepare. Sometimes he was left a little 'product, not sterilized, which is usually thrown away. But one day a colleague asked him to try it on one of our nurses that he was losing his hair. "
One case, but not very unfortunate: that solution still has something to do with hair loss.
"It is known that prostaglandin E1 acts on the endothelial cell receptors by stimulating growth of new capillaries by improving the functions of the skin cells. It also produces a vasodilatation of these which can determine the healing of skin diseases and improve the blood flow of the hair bulb ».
So you are not surprised that much when that experiment has been successful?
"But I was impressed very much, I did not believe their own. Until today alopecia is not understood much, it goes for attempts. This drug is a complex product that has evidently something more of the products tested until now. I am a scholar and yet I continue to look for comparisons, although, frankly, these successes have impressed me a lot. "
Among the first experiments there was also a little girl?
"Children usually respond well. That case was very serious, the first serious case, which has given us great satisfaction. That baby is now a real cappellona ".
On how many subjects you have tried?
"For now only 25, all on the mend. It is not easy to create this solution, and in any case do not forget that these experiments we have a corollary to basic research. But given the results and demands, we have already contacted some pharmaceutical companies to carry out the lotion and put it in large-scale disposal. "
How old are your patients?
"The oldest is 66 years old a menopausal woman: two years does not lose more hair. The youngest is 5 years old, is a very sweet girl and, like all children, terrified of injections. I believe that I would not have hurt, and finally it is left to cure. These days are rispuntando the first hair. Now I'm trying the product on adults, but the lotion is almost over. I hope that also functions on them. The result depends on many factors, including the state of health of the hair bulb that sometimes does not immediately die. " A delicate phase in which all look very cautious, but it seems that this time there are quite a bit of good reasons to hope. At least 25.
Alessandra Raggio
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Do you suspect the blocking of 5ar, not DHT is the culprit for sides with Finasteride then?
So hypothetically speaking if you can keep 5ar which is necessary for sexual function (is that correct?) but still block DHT which chokes your follicles you can get the benefits without the sides?
It's a shame you cannot just digest S-Equol orally and be done with it. Do you know why absorption is so hard?