Stemson is going to use minipigs in the next stage of their hair cloning research

[Pls_NW-1]

You dont need! Its your own choice .
Google dr zarev . And see how his 12k restore ppl with high nws like nw7-6. They look like they not even balding . My end point is that you dont need to spend alot of money to restore normal look as you may think. So when the tech is out we are good we just need it to be somthing real .

Don't be delusional... people are always greedy.

 

[trialAcc]

You dont need! Its your own choice .
Google dr zarev . And see how his 12k restore ppl with high nws like nw7-6. They look like they not even balding . My end point is that you dont need to spend alot of money to restore normal look as you may think. So when the tech is out we are good we just need it to be somthing real .

Most people do not have 12k grafts available though!

 

[Pls_NW-1]

That why i said 7k ... the rest 3k would be from stemson.

No, you wont get only 3k grafts. You will get all grafts. Full coverage. You dont need the 7k from harvesting the donor. Stemson, if it works, will restore ALL your hair, without touching the donor.

 

[Pls_NW-1]

Would be crazy if stemson's technology would provide for someone a hairline like Zayn Malik's lol.

But that... sounds more like a dream.

 

[eeyore]

It's not in vitro. They have developed their tech on mice with human skin.

They may have started pre clinical studies with the minipigs already. If not, they will start soon.

My guess is best case scenario they finish the studies with minipigs in the second half of 2022 and start planing the clinical trials from there.

Wait human skin on mice, how does that work, they cut off a patch from a mouse? If that's the case then that's pretty good for their success rate if they already did it on human skin isn't it?

Do you have a source for Tsuji not really cloning hair? I couldn't find a source.

As for all the people who say cloning hair on mice has been a thing since the 1980s I spent over an hour and found no source of that.

Also, I hope Dr. Terskikh is able to do everything himself and that the histotechnician is just for repetitive work he doesn't want to do himself. I'd be horrible for their timeline if they're stalled waiting for one.

 

[eeyore]

It's not in vitro. They have developed their tech on mice with human skin.

They may have started pre clinical studies with the minipigs already. If not, they will start soon.

My guess is best case scenario they finish the studies with minipigs in the second half of 2022 and start planing the clinical trials from there.

Wait human skin on mice, how does that work, they cut off a patch from a mouse? If that's the case then that's pretty good for their success rate if they already did it on human skin isn't it?

As for all the people who say cloning hair on mice has been a thing since the 1980s I spent over an hour and found no source of that.

You dont need! Its your own choice .
Google dr zarev . And see how his 12k restore ppl with high nws like nw7-6. They look like they not even balding . My end point is that you dont need to spend alot of money to restore normal look as you may think. So when the tech is out we are good we just need it to be somthing real .

That's true, but also with 12k you'd still look bald under harsh lighting and strong wind. Also if you're NW5+ and want to go swimming at the beach again one day without looking like there's an octopus monster on your head you'd probably need at least 30k.

 

[werefckd]

Wait human skin on mice, how does that work, they cut off a patch from a mouse? If that's the case then that's pretty good for their success rate if they already did it on human skin isn't it?

Do you have a source for Tsuji not really cloning hair? I couldn't find a source.

As for all the people who say cloning hair on mice has been a thing since the 1980s I spent over an hour and found no source of that.

Also, I hope Dr. Terskikh is able to do everything himself and that the histotechnician is just for repetitive work he doesn't want to do himself. I'd be horrible for their timeline if they're stalled waiting for one.

I edited my post, I meant human cells, not skin. Although they may have used human skin but I couldn't find anything about it now.

Regarding Tsuji, the source is their Nature article from 2012, although I noticed now that they say they cultured the DP cells (but not the epithelium cells) so I'm not to sure. See attached file.

Regarding Stemson, don't worry they already have other scientists in the company

 

[Pls_NW-1]

When stemson is literally a cure to hairloss, we (my family lol) will send my father to them as a test subject lmao. He has literally androgenetic alopecia TOTALIS, no hair.

 

[jan_miezda]

And then now they want multiply hair follicles on minipigs with human skin?
It is a fantastic idea imo

I know you said pig skin is similar in structure to human skin. is the hair cycle of pig similar too? mice hair renewal is every few weeks and pig is every few years

 

[jan_miezda]

The real question is the pig hair deal with androgens that attacks his folicels?

i wish stemson used primate model instead of pig but pig is still a big step up. Even if they can engineer an entire hair, while follica and other treatments are released it can be good

 

[jan_miezda]

Folica is very sketchy , 10 years for minoxidil and some adavnced dermapen. I dont trust these kind of treatment

read in the follica thread. there are good trich. images that show great results. SHT and follica can be ultimate combination without having to take other pharmaceuticals

 

[kiwi666]

I was just saying the truth.
Even if stemson is going to figure out hair multiplication, we will, even with a big MAYBE, have access to it in 10-15years+. 20 years is more realistic.
I just don't want that people get dissapointed or that their expectations aren't meeting with reality, that's it.

Sorry then, for spreading a bad atmosphere around here.

You’re not saying the truth. You’re speculating.

There are men walking around out there that have been part of various trials and would probably beg to differ to your opinion.

I think it pays to not talk about dates either optimistically or pessimistically because you’ll probably be wrong.

 

[Armando Jose]

I know you said pig skin is similar in structure to human skin. is the hair cycle of pig similar too? mice hair renewal is every few weeks and pig is every few years

the structure of the skin of pigs in relation to hair is very similar to that of humans, depth, grouping, etc.
But only primates more evolved also sharepartly the asynchrony of the hair with respect to the hair cycle.

 

[Armando Jose]

The real question is the pig hair deal with androgens that attacks his folicels?

the metabolism of androgens for hair is very similar in all mammals, especially when the important ones are manufactured in the same pilosebaceous follicle

i have tons of hyper responder to minoxidil . But they lose all the gains in some point

Any med that continually alters the hair cycle, over time will alter it irreversibly.

 

[Pls_NW-1]

I get it! But as i said . If its money prbolem you still can make it cheaper by taking most of your donor zone and leave the rest for stemson.
plus for your information you can restore full density , you can transplant that many close folicels its impossible to this date. It will cause damge to the folicele around it . I think the most you can go is around 60 graft for cm.
(Whic is amazing ) but you can get full head look with 45 graft per cm . So we dont need to spend that much to get good look

But stemson developed a scaffold, they wont get implanted with FUE. So they can manage a natural density... Will they!?

 

[NorwoodGuardian]

the metabolism of androgens for hair is very similar in all mammals, especially when the important ones are manufactured in the same pilosebaceous follicle

Any med that continually alters the hair cycle, over time will alter it irreversibly.

What means by alter it irreversibly? so the hair cycle will become normal?

 

[Pls_NW-1]

I don't understand what is being discussed here.

@Roeysdomi says that it wont be possible to fully restore a full head of hair with natural density as grafts can't be placed that close, to give natural density, which is true.

But Stemson won't use the usual transplanting methods etc. they won't implant every single graft, much rather the scaffold with all the DP cells growing in a natural pattern...
I'm quite unsure still. Someone can clear this up?! Thanks!

 

[Pls_NW-1]

even Tsuji said they can do 126 hairs per square centimeter. I think we shouldn't bother with that. If Stemson is successful, we will have no more problems with our hair loss.

Well, I thought about the stemson approach a lot and about the whole male pattern baldness thing, trying to find research and other papers and stuff.

The fact is that Androgen signaling/ AR signaling needs to be deactivated in scalp tissue.

With stemson you wont clear that up, you just create new hair there, which will again fail in some matter of time due to ANDROGENs; which will most likely KILL them off again. Even scalp tissue changes through androgen signaling, not giving the follicles a great environment to grow.


I think the next thing to a cure is doing botox 2 times a year or so on scalp + stemson + AR degrader topically.

 

[frank33]

even Tsuji said they can do 126 hairs per square centimeter. I think we shouldn't bother with that. If Stemson is successful, we will have no more problems with our hair loss.

126 hair per square centimeter are actually about 60 grafts

by the way i think that technology limits regarding density will be easily surpassed once cloning comes out.
they haven't yet just because there is no need to, bottle cap at the moment is in grafts quantity

Dr. Zarev is the living proof that 12k grafts will be a cure even for NW7

 

[Armando Jose]

What means by alter it irreversibly? so the hair cycle will become normal?

Sorry for not expressing myself well, what I mean is that any drug capable of altering the hair cycle will cause a loss of natural asynchrony and over time will carry out generalized hair loss phases.