Stemson is going to use minipigs in the next stage of their hair cloning research

[Keratinpro]

You apply?

I already applied and got accepted. I might be taking your boy buzzlighter with me, you two might want to talk it out

 

[Super Metroid]

If that would be the case, baldness wouldn't exist. The hair follicle gets over time more sensitive due to genetic predisposition. It's like -> aging. The genetic × hormone combo plays a big role.

This applies to the situation where you clone existing follicles, and place them on your head at a later age.

 

[Super Metroid]

That's what I'm saying, but what percentage of people who lose their hair lose it at 20~? Maybe 5-10% tops? Actually bald at 19-22? Under 5% for sure.

Anyways, I still don't think it matters. If this literal revolutionary technology works in humans, the last thing people are going to be concerned about is if they need to replicate the process unless that also comes with significant costs. People are just going to be happy that a solution exists if they want one.

The more the process needs to be repeated, the cheaper it will have to be each time anyways.

I notice that we tend to overestimate peoples' financial situations. Everybody agrees that the price Tsuji wanted to ask was way too high, but to then point towards the ~$50k price tag of Stemson as "being available to the common man" is way too optimistic. Most people live paycheck to paycheck and would be willing and able to pay such amounts only for necessities, such as a car or house, or investments. This treatment is neither.

Most of the people who could afford it, will likely only be able to pay for the procedure once. So if results aren't guaranteed for a lifetime, that should make you rethink the decision to undergo this procedure.

 

[Norwoody]

I already applied and got accepted. I might be taking your boy buzzlighter with me, you two might want to talk it out
View attachment 163385

You might want to consider buzzing it like him

 

[Keratinpro]

You might want to consider buzzing it like him

If you want a comeback from me you’re gonna have to scrape it out of your mother’s teeth.

 

[trialAcc]

I like this positive and hopeful interpretation of their listings.

Yeah I just want there to be a cure first before I start worrying about things like price, durability, etc. Doesn't matter if it's via drugs or hair cloning, and whether it's inconvenient or expensive.

Losing hair is a lot less stressful once you know there is a way to get it back. I actually don't think it would be very stressful at all anymore if you knew you could get this procedure at anytime.

I notice that we tend to overestimate peoples' financial situations. Everybody agrees that the price Tsuji wanted to ask was way too high, but to then point towards the ~$50k price tag of Stemson as "being available to the common man" is way too optimistic. Most people live paycheck to paycheck and would be willing and able to pay such amounts only for necessities, such as a car or house, or investments. This treatment is neither.

Most of the people who could afford it, will likely only be able to pay for the procedure once. So if results aren't guaranteed for a lifetime, that should make you rethink the decision to undergo this procedure.

I don't think anyone assumes that the common person could afford 50k out of pocket, but it's something that is achievable to a working professional with saving/financing.

 

[Chads don't bald]

Why is everyone saying the cloned follicles will be susceptible to DHT?

I thought the whole point was to clone follicles that are not susceptible to DHT (such as the ones on the back of your head), so it is more like an unlimited hair transplant. Or am I misunderstanding the technique?

 

[Keratinpro]

Why is everyone saying the cloned follicles will be susceptible to DHT?

I thought the whole point was to clone follicles that are not susceptible to DHT (such as the ones on the back of your head), so it is more like an unlimited hair transplant. Or am I misunderstanding the technique?

There hasn’t been information released on whether the follicles will be or will not be resist to DHT. You might be thinking of Tsuji’s/Yokohoma method?

 

[Marcaronii]

Has anyone seen replicel's news letter? What do you think they'll do now that they have their dermal injector ready?

 

[Keratinpro]

The problem is that you assume that stemson will replicate the high quality folicele that created when your born. I doubt that. But i agree it should take a while for the hair to go. I dont think its a problem as long as you can repeat the process

But aren’t the hair follicles being derived from neural crest? Won’t that mean the follicles would be relatively similar to ones you were born with?

 

[Keratinpro]

I look at the hairs that comes out from the mouse...
They look very weird and frizzy . Not human like hair. (And those hair were from human).

You’re partially correct my man. Hair growth in nude mice transplanted with human iPSC-derived dermal papilla cells that were combined with mouse epithelial cells inside a biodegradable scaffold. The epithelial was that of mice. Also Alexey was saying that the biological part of his procedure was solved, he was now looking into how to create robust hair with the technology. “Terskikh studies a type of cell called dermal papilla. Residing inside the hair follicle, these cells control hair growth, including hair thickness, length and growth cycle.”

 

[Keratinpro]

Just to be clear i wont mind to have this friizzy hair . I would just buzzcut and look good even with that . So in the worth case its still good

Fair enough, but from what I understand you can control the hair length, thickness and growth cycles according to how much dermal papilla you want packed. So it’s up to you really.

 

[eeyore]

You’re partially correct my man. Hair growth in nude mice transplanted with human iPSC-derived dermal papilla cells that were combined with mouse epithelial cells inside a biodegradable scaffold. The epithelial was that of mice. Also Alexey was saying that the biological part of his procedure was solved, he was now looking into how to create robust hair with the technology. “Terskikh studies a type of cell called dermal papilla. Residing inside the hair follicle, these cells control hair growth, including hair thickness, length and growth cycle.”

Yeah that was just a proof of concept. They're not going to be able to sell their product if the final thing looks like transplanted pubes.

 

[Keratinpro]

Yeah that was just a proof of concept. They're not going to be able to sell their product if the final thing looks like transplanted pubes.

Exactly what I mean, it needed fine tuning from then all the way to commercialization. That’s why it’s going to be interesting to see proof of concept on pigs to see what kind of improvements have been made in the appearance of the hair follicles. Mainly because of its close proximity to human skin.

 

[H]

Exactly what I mean, it needed fine tuning from then all the way to commercialization. That’s why it’s going to be interesting to see proof of concept on pigs to see what kind of improvements have been made in the appearance of the hair follicles. Mainly because of its close proximity to human skin.

When are we supposedly seeing this proof of concept anyway?

 

[Chads don't bald]

You might be thinking of Tsuji’s/Yokohoma method?

Oh ok honestly I thought the methods were similar for Stemson as well. But apparently they create a folliculogenic cell from scratch.

Now I'm wondering whether it would be possible for them to genetically engineer these cells in vitro to be DHT resistant before transplanting them into our scalps. That would be pretty convenient and we do have the technology for single gene knockouts.

 

[Keratinpro]

Oh ok honestly I thought the methods were similar for Stemson as well. But apparently they create a folliculogenic cell from scratch.

Now I'm wondering whether it would be possible for them to genetically engineer these cells in vitro to be DHT resistant before transplanting them into our scalps. That would be pretty convenient and we do have the technology for single gene knockouts.

That’s the million dollar question that only Alexey and his team would know. But gene knockout does sound extremely pricey.

 

[Chads don't bald]

But gene knockout does sound extremely pricey.

Well you would only need to do it once, and then clone that cell over and over.

I think the price would be worth it to make it DHT resistant. I'm sure Stemson would offer both though at different price points.

 

[Wispy]

Does it have to be DHT resistant? If it's cheap and easy to apply, just...do it every few months to offset loss. Better something than nothing.

 

[Pls_NW-1]

Does it have to be DHT resistant? If it's cheap and easy to apply, just...do it every few months to offset loss. Better something than nothing.

You will literally never be able to grow (perfect) hair. I wouldn't like to do the procedure just for a little grown out buzz cut lol.

Edit; nobody knows if it will even grow on the scalp (if it is indeed not androgen resistant) for androgenetic alopecia patients.