Stemson is going to use minipigs in the next stage of their hair cloning research

[Chads don't bald]

So what's your opinion on Aubrey de Grey and all his talk on repairing the damage the body does to itself?

Ik you didn't ask me but I think his approach is sound. The hallmarks of aging have already been identified. Therapies which address the hallmarks are in development. Some are already in human trials (such as senolytics). Other therapies such as epigenetic reprogramming (to reverse epigenetic markers of aging) are in preclinical stage.

I don't think we will "cure" aging within the next 50 years, no way. But I do think we will have enough therapies to extend our life so we can buy more time for there to be a cure. This is basically what the concept of longevity escape velocity is - extend life by more than 1 year for every year that goes by.

This is not even taking into account the impact AI may have on biotechnology: https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery

Using history to predict the future is stupid imo. 50 years ago people probably used to put coconut oil on their heads to treat hair loss. 50 years from now baldness won't even be a problem because we will use gene editing technology to edit any baldness genes out of our scalp tissues.

 

[DuncanOP]

Ik you didn't ask me but I think his approach is sound. The hallmarks of aging have already been identified. Therapies which address the hallmarks are in development. Some are already in human trials (such as senolytics). Other therapies such as epigenetic reprogramming (to reverse epigenetic markers of aging) are in preclinical stage.

I don't think we will "cure" aging within the next 50 years, no way. But I do think we will have enough therapies to extend our life so we can buy more time for there to be a cure. This is basically what the concept of longevity escape velocity is - extend life by more than 1 year for every year that goes by.

This is not even taking into account the impact AI may have on biotechnology: https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery

Using history to predict the future is stupid imo. 50 years ago people probably used to put coconut oil on their heads to treat hair loss. 50 years from now baldness won't even be a problem because we will use gene editing technology to edit any baldness genes out of our scalp tissues.

I think is more easy to we get a """cure""" in few years (around 5) instead of increase our lifetime.

This video is pretty old. But I have fun about the doctor saying this is decades away and never can go to market.
Companies like Stemson, Riken and so on are not wasting and will waste time and money for nothing

 

[trialAcc]

Ik you didn't ask me but I think his approach is sound. The hallmarks of aging have already been identified. Therapies which address the hallmarks are in development. Some are already in human trials (such as senolytics). Other therapies such as epigenetic reprogramming (to reverse epigenetic markers of aging) are in preclinical stage.

I don't think we will "cure" aging within the next 50 years, no way. But I do think we will have enough therapies to extend our life so we can buy more time for there to be a cure. This is basically what the concept of longevity escape velocity is - extend life by more than 1 year for every year that goes by.

This is not even taking into account the impact AI may have on biotechnology: https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery

Using history to predict the future is stupid imo. 50 years ago people probably used to put coconut oil on their heads to treat hair loss. 50 years from now baldness won't even be a problem because we will use gene editing technology to edit any baldness genes out of our scalp tissues.

I think with out catastrophe between now and then, base ageing will be long solved and implemented in 50 years. Cellular reset and unlimited tissue/bone/cartilage regeneration. Neural degeneration will be more difficult to crack but still should be more or less perfected in 50~ years time. I don't know what the outlook will be for max lifespan though, but it's also not that far of a stretch to think that the human conscious will be fully mapped and compatible with machine interfaces that could preserve life indefinitely.

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I think it's a massive mistake/error to try and compare the last 50 (or the 40 before the last 10) with what the next 50 will be in terms of scientific and health advancements. Even with diminishing returns in production, a year or two now is easily worth more then a decade of research in the 60s-90s. I can screen hundreds of thousands of compounds in my bedroom using python and a ML model against different conditions and gene expressions, something that it would have taken a lab full of Masters students months to parse through in the 80s or 90s. It's a completely different era of science.

 

[froggy7]

I think with out catastrophe between now and then, base ageing will be long solved and implemented in 50 years. Cellular reset and unlimited tissue/bone/cartilage regeneration. Neural degeneration will be more difficult to crack but still should be more or less perfected in 50~ years time. I don't know what the outlook will be for max lifespan though, but it's also not that far of a stretch to think that the human conscious will be fully mapped and compatible with machine interfaces that could preserve life indefinitely.

What about sex after mind mapping?

 

[Chads don't bald]

I can screen hundreds of thousands of compounds in my bedroom using python and a ML model against different conditions and gene expressions,

Yup they're already using AI for drug discovery. Eventually they'll use AI for much more. The next 50 years is the biotech revolution, like the last 50 was the tech revolution.

What about sex after mind mapping?

You still won't get laid bro

 

[soull]

Stemson Therapeutics Raises $15M To Bolster Hair Regeneration Efforts - Follicle Thought

The company founded on Alexey Terskikh’s hair multiplication research at the Sanford Burnham Prebys Institute has not had a problem raising capital since its inception a few years ago. In a press release issued today, July, 15, 2021, Stemson Therapeutics announced the closing of a $15 million...

www.folliclethought.com

 

[froggy7]

"We are well aware the history of false promises, over-hype and failed attempts to develop hair loss solutions. While I cannot yet promise we will succeed, I can project new hope that a serious and highly reputable team of expert scientists, cell biologists, bioengineers, bioinformaticians, biotech executives, biotech investors, and therapeutics developers have come together at Stemson Therapeutics to make an earnest attempt at applying the latest breakthrough technologies in therapeutics to solve hair loss once and for all."

an old melody from the past .....


"To be sure, generating hair follicles is an extremely difficult challenge to solve. Controlling and directing live biology is hard. It will involve a multi-disciplinary approach including cellular reprogramming, biomaterial engineering, tissue engineering, machine learning and analysis of biological data, and robotic transplantation solutions."

where are the optimists who saw the $ 50k price tag.......

 

[MrV88]

If Tsuji will succeed and be less expensive I will laugh my bald *** off

 

[DuncanOP]

Stemson Therapeutics Raises $15M To Bolster Hair Regeneration Efforts - Follicle Thought

The company founded on Alexey Terskikh’s hair multiplication research at the Sanford Burnham Prebys Institute has not had a problem raising capital since its inception a few years ago. In a press release issued today, July, 15, 2021, Stemson Therapeutics announced the closing of a $15 million...

www.folliclethought.com

Well, it is a good news by a way. Thanks for sharing.

But unfortunally, he didn't give me confidence that they will find the solution. Now, my best expectation of hair clone will be from Yokohoma University.

"To be sure, generating hair follicles is an extremely difficult challenge to solve. Controlling and directing live biology is hard. It will involve a multi-disciplinary approach including cellular reprogramming, biomaterial engineering, tissue engineering, machine learning and analysis of biological data, and robotic transplantation solutions."

where are the optimists who saw the $ 50k price tag.......

"to solve hair loss once and for all"
The price don't seens to be a "big issue" for me at the moment.
The biggest problem should be the time and the chance to develop it.
For sure from his letter the solution is too far yet.

The news I want to see from Stemson, at the moment, is the reason of this topic. The result from tests with the minipigs.
Hope this is going fine since they are getting investors.

 

[eeyore]

"We are well aware the history of false promises, over-hype and failed attempts to develop hair loss solutions. While I cannot yet promise we will succeed, I can project new hope that a serious and highly reputable team of expert scientists, cell biologists, bioengineers, bioinformaticians, biotech executives, biotech investors, and therapeutics developers have come together at Stemson Therapeutics to make an earnest attempt at applying the latest breakthrough technologies in therapeutics to solve hair loss once and for all."

an old melody from the past .....


"To be sure, generating hair follicles is an extremely difficult challenge to solve. Controlling and directing live biology is hard. It will involve a multi-disciplinary approach including cellular reprogramming, biomaterial engineering, tissue engineering, machine learning and analysis of biological data, and robotic transplantation solutions."

where are the optimists who saw the $ 50k price tag.......

He's being realistic. Everyone else tries to hype themselves up saying they have a cure after growing hair in mice. Stemson is the only company taking hair cloning seriously.

I think $50-$100k is still possible. They're developing their solution with the intention of scaling which will definitely mean huge investments into R&D and equipment that they should be able to recoup from the velocity of treatments.

 

[froggy7]

He's being realistic. Everyone else tries to hype themselves up saying they have a cure after growing hair in mice. Stemson is the only company taking hair cloning seriously.

I think $50-$100k is still possible. They're developing their solution with the intention of scaling which will definitely mean huge investments into R&D and equipment that they should be able to recoup from the velocity of treatments.

50-100k$ it would be avery goood price!

 

[froggy7]

Only good news here is that Semson is still trying.
valuable news will be when they present the results of preclinical tests on pigs, everyone had money before them and no one provided anything

 

[froggy7]

"This round of financing will be applied to advancing Stemson’s cell engineering platform, which involves bioengineered material and will be combined with robotic delivery as a novel solution for hair replacement, according to the release. It appears Stemson has theorized that the placement of its stem cell mixtures within scaffolding will be best handled by robots for precise insertion into scalp tissue. It’s also mentioned that Stemson is currently developing a human skin environment model implanted onto larger animals (likely a pig or miniature pig). This will allow Stemson to test out their implantation processes in an environment as similar to human as possible before starting an official clinical trial. Good stuff."

it looks like the pig trials haven't started yet

 

[eeyore]

"This round of financing will be applied to advancing Stemson’s cell engineering platform, which involves bioengineered material and will be combined with robotic delivery as a novel solution for hair replacement, according to the release. It appears Stemson has theorized that the placement of its stem cell mixtures within scaffolding will be best handled by robots for precise insertion into scalp tissue. It’s also mentioned that Stemson is currently developing a human skin environment model implanted onto larger animals (likely a pig or miniature pig). This will allow Stemson to test out their implantation processes in an environment as similar to human as possible before starting an official clinical trial. Good stuff."

it looks like the pig trials haven't started yet

It's disappointing timeline wise with the pig trials but with this press release I'm more hyped for Stemson than ever as it shows how serious they are about actually curing hair loss. To me it looks like they're carefully developing their solution to be as robust and commercially viable as possible.

 

[DuncanOP]

"This round of financing will be applied to advancing Stemson’s cell engineering platform, which involves bioengineered material and will be combined with robotic delivery as a novel solution for hair replacement, according to the release. It appears Stemson has theorized that the placement of its stem cell mixtures within scaffolding will be best handled by robots for precise insertion into scalp tissue. It’s also mentioned that Stemson is currently developing a human skin environment model implanted onto larger animals (likely a pig or miniature pig). This will allow Stemson to test out their implantation processes in an environment as similar to human as possible before starting an official clinical trial. Good stuff."

it looks like the pig trials haven't started yet

Thanks for sharing.

And whata hell. They test it on small animals successfully. Now they are wasting time trying to "mock" the human skin to improve the tests in big animals?( "development efforts are focused on developing an optimized solution for human skin structure environment in larger animal models.")

Lmao, I'm sure a high number of users will not care about test it.. damn governement laws.

 

[FilthyFrancis]

Good news they attracted new investors. These people have much more information on the company (and are most likely more knowledgeable on biotech) than we do. If money keeps flowing, it means investors consider the risk benefit ratio worth it.

I wouldn't overthink his realistic statement. It's a challenge and he is simply acknowledging it. Better this than someone who promises the moon *cough*Tsuji*cough cough*

 

[froggy7]

it is unlikely to receive any positive news about pig testing this year

 

[trialAcc]

Leave it to a hairloss forum to decide that 15 million in early stage funding from massive biotech and VC firms can possibly be seen as a negative simply because the CEO admitted in a press release that what they are trying to accomplish is incredibly difficult.

People were willing to bet all their cope/hope on things like Tsuji (begging for dollars on twitter and wanting to charge you 700k USD to be in his trial), Replicel (entire firm valued less then this Series A alone), Histogen (entire firm valued under 10 million after raising tens of millions over a decade from no name investors) and dozens of other shitty products and companies over the years that had no where near the legitimacy or backing that this company does.

Keep in mind here that the private valuation of his firm is likely anywhere between 50 to 100 million now. The only other thing that's come around in the last 2~ decades that has the same legitimacy of this company/process is the recent HopeMed series B that put that company well into the hundreds of millions valuation wise. Recognize that this type of money doesn't flow into something like hairloss without serious potential and hype behind the science.

 

[froggy7]

Leave it to a hairloss forum to decide that 15 million in early stage funding from massive biotech and VC firms can possibly be seen as a negative simply because the CEO admitted in a press release that what they are trying to accomplish is incredibly difficult.

People were willing to bet all their cope/hope on things like Tsuji (begging for dollars on twitter and wanting to charge you 700k USD to be in his trial), Replicel (entire firm valued less then this Series A alone), Histogen (entire firm valued under 10 million after raising tens of millions over a decade from no name investors) and dozens of other shitty products and companies over the years that had no where near the legitimacy or backing that this company does.

Keep in mind here that the private valuation of his firm is likely anywhere between 50 to 100 million now. The only other thing that's come around in the last 2~ decades that has the same legitimacy of this company/process is the recent HopeMed series B that put that company well into the hundreds of millions valuation wise. Recognize that this type of money doesn't flow into something like hairloss without serious potential and hype behind the science.

I also hope that this time this company will do it, but so far there are only words and no positive human trials

 

[DuncanOP]

Leave it to a hairloss forum to decide that 15 million in early stage funding from massive biotech and VC firms can possibly be seen as a negative simply because the CEO admitted in a press release that what they are trying to accomplish is incredibly difficult.

People were willing to bet all their cope/hope on things like Tsuji (begging for dollars on twitter and wanting to charge you 700k USD to be in his trial), Replicel (entire firm valued less then this Series A alone), Histogen (entire firm valued under 10 million after raising tens of millions over a decade from no name investors) and dozens of other shitty products and companies over the years that had no where near the legitimacy or backing that this company does.

Keep in mind here that the private valuation of his firm is likely anywhere between 50 to 100 million now. The only other thing that's come around in the last 2~ decades that has the same legitimacy of this company/process is the recent HopeMed series B that put that company well into the hundreds of millions valuation wise. Recognize that this type of money doesn't flow into something like hairloss without serious potential and hype behind the science.

of course Stemson have credits and I'm not questioning its potential for the hair loss market or comparing them with these other ""scams""..

But I'm criticizing the purpose of the letter from the CEO. What is the reason of it?

Basically, he said (and everything are true) that baldness is a considerable problem, the solutions provided to it until now are disheartening, they are rising money to invest in the solution, but it is difficult to get it and they are just starting.

Neutral points:
- bla bla bla about problems of hair loss, emotional history and bad products at market until now.

Negative points:
1) They are just starting the pipeline
2) He didn't guarantee anything
3) Is hard to obtain the solution

Positive points:
1) They are rising money and are serious to try to provide a product to "cure" baldness (but I think we can compare this positive points with the "others". Every big player in this market are seriuous to bring hair loss cure, so, this point is not very useful)

For me, this letter was not a good choice, even for businesses logic. It would been better/interesting to just announced the partnership and written down advances of their current research.
Instead of publish this bad letter, which looks like a candlelight close to a darkness that itself brings