Stemson is going to use minipigs in the next stage of their hair cloning research

[trialAcc]

of course Stemson have credits and I'm not questioning its potential for the hair loss market or comparing them with these other ""scams""..

But I'm criticizing the purpose of the letter from the CEO. What is the reason of it?

Basically, he said (and everything are true) that baldness is a considerable problem, the solutions provided to it until now are disheartening, they are rising money to invest in the solution, but it is difficult to get it and they are just starting.

Neutral points:
- bla bla bla about problems of hair loss, emotional history and bad products at market until now.

Negative points:
1) They are just starting the pipeline
2) He didn't guarantee anything
3) Is hard to obtain the solution

Positive points:
1) They are rising money and are serious to try to provide a product to "cure" baldness (but I think we can compare this positive points with the "others". Every big player in this market are seriuous to bring hair loss cure, so, this point is not very useful)

For me, this letter was not a good choice, even for businesses logic. It would been better/interesting to just announced the partnership and written down advances of their current research.
Instead of publish this bad letter, which looks like a candlelight close to a darkness that itself brings

The letter he wrote just highlighted the difficultly of the challenge they are undertaking and built up the significance of what they are trying to achieve by emphasizing with the mass emotional toll that hairloss pushes onto people.

It's very possible they got delayed in the timing of their pre-clinical research but its very difficult to see the CEO standing there with a fresh 15m dollar check from a new biotech investor and think this could be a negative. They're also developing the robotics that will have this process quick, cheaper, and far more natural then most transplant surgeons could accomplish.

 

[DuncanOP]

It's very possible they got delayed in the timing of their pre-clinical research but its very difficult to see the CEO standing there with a fresh 15m dollar check from a new biotech investor and think this could be a negative

Indeed, Stemson seems to care about trying to create a process that is financially viable for most people. And I didn't pay enough attention to this.

I still think the CEO letter could have been a little better, maybe providing time expectations or timeline details. But it's better than nothing, certainly. And you commented on its good points.

 

[froggy7]

Indeed, Stemson seems to care about trying to create a process that is financially viable for most people. And I didn't pay enough attention to this.

I still think the CEO letter could have been a little better, maybe providing time expectations or timeline details. But it's better than nothing, certainly. And you commented on its good points.

it's good that they have solid financing and want to use the robot, we still do not know if the hair will be permanent, but probably by using other solutions it will be possible to achieve it? besides, stemson will produce the hair that someone wants, as long as is completely bald, which is a big plus

 

[froggy7]

AbbVie-backed Stemson snags $15M series A for hairy brush-up with Rogaine, Propecia

AbbVie wants more people to regain the pleasure of going to a barbershop or local hair salon, and the biopharma has a keen eye for aesthetics. | AbbVie's Allergan Aesthetics unit, famous for Botox, is among the investors pouring $15 million into Stemson Therapeutics, which sees itself a first...

www.fiercebiotech.com

"We don’t know when exactly we’ll get into human clinical trials, but we’ve got a couple of years in front of us to really try to complete the R&D to the point where we have confidence and we’ll just have to see how we progress along that timeline,” Hamilton said. The preclinical work is currently being done in animal models that "can very closely approximate the human skin structure and environment," the CEO said."

 

[DuncanOP]

AbbVie-backed Stemson snags $15M series A for hairy brush-up with Rogaine, Propecia

AbbVie wants more people to regain the pleasure of going to a barbershop or local hair salon, and the biopharma has a keen eye for aesthetics. | AbbVie's Allergan Aesthetics unit, famous for Botox, is among the investors pouring $15 million into Stemson Therapeutics, which sees itself a first...

www.fiercebiotech.com

"We don’t know when exactly we’ll get into human clinical trials, but we’ve got a couple of years in front of us to really try to complete the R&D to the point where we have confidence and we’ll just have to see how we progress along that timeline,” Hamilton said. The preclinical work is currently being done in animal models that "can very closely approximate the human skin structure and environment," the CEO said."

yes, as I said, that is one the negative points. He should be more specific, this vague sentence gives the impression that will take several years, which is disheartening.

My top 1 expectation about hair clone at the near future is Yokohama, because the approach of trying to clone hair cells using germ cells seems more feasible to me, rather than Stemson's approach of taking cells from the blood and differentiating them.
But maybe a big player enter in this area in the near future too, who knows?


I also find it a bit strange that they are focusing in techniques with robots instead of using all their blinds to perform a POC on humans.
A successful POC would certainly attract alot of investors, since no ones performed something like it yet.

 

[Ghc]

The preclinical work is currently being done in animal models that "can very closely approximate the human skin structure and environment," the CEO said

So they started test on pigs?

 

[froggy7]

So they started test on pigs?

am i stemson CEO?

 

[Ghc]

am i stemson CEO?

No but use your brain, this is an only logical conclusion, pigs are similar to humans and mouse is not.

 

[DuncanOP]

So they started test on pigs?

Probably not

@Edit: Sorry, it is not from letter.

"...Currently, Stemson’s research and development efforts are focused on developing an optimized solution for human skin structure environment in larger animal models..." (https://www.businesswire.com/news/h...ecures-15M-Series-A-Funding-to-Cure-Hair-Loss)

So, they are developing. It does not imply in testing, I think

 

[froggy7]

“We don’t know when exactly we’ll get into human clinical trials, but we’ve got a couple of years in front of us to really try to complete the R&D to the point where we have confidence and we’ll just have to see how we progress along that timeline,” Hamilton said. The preclinical work is currently being done in animal models that “can very closely approximate the human skin structure and environment,” the CEO said.”

 

[trialAcc]

Probably not

@Edit: Sorry, it is not from letter.

"...Currently, Stemson’s research and development efforts are focused on developing an optimized solution for human skin structure environment in larger animal models..." (https://www.businesswire.com/news/h...ecures-15M-Series-A-Funding-to-Cure-Hair-Loss)

So, they are developing. It does not imply in testing, I think

Why are you splitting hairs (hah)? They are working on growing hair on pigs, it doesn't matter which part of the process they are on. It's all pre-clinical research until they deem it to be completed and get approval to move to humans.

 

[froggy7]

Why are you splitting hairs (hah)? They are working on growing hair on pigs, it doesn't matter which part of the process they are on. It's all pre-clinical research until they deem it to be completed and get approval to move to humans.

Better let them refine the technologies well, I like the robot solution very much, they are moving forward and that's the most important thing

 

[DuncanOP]

Why are you splitting hairs (hah)? They are working on growing hair on pigs, it doesn't matter which part of the process they are on. It's all pre-clinical research until they deem it to be completed and get approval to move to humans.

Haha, everyone who has hair loss genes are afraid to go bald to the point that the only possible solution is hair cloning.
I'm still young, current at NW3 and stabelized. But I (and I think many other users) really want hair clone to be available in the case that the actual market solutions are not enough to hold a good hair in the future.

Then any less-than-optimistic post from one of the biggest players is worrisome.

And yes, all are at the pre-clinical stage until it comes to humans. But release of the result of tests with pigs soon will be more interesting than others pre-clinical results. Since their skin is more similar to humans than rats.

 

[froggy7]

Haha, everyone who has hair loss genes are afraid to go bald to the point that the only possible solution is hair cloning.
I'm still young, current at NW3 and stabelized. But I (and I think many other users) really want hair clone to be available in the case that the actual market solutions are not enough to hold a good hair in the future.

Then any less-than-optimistic post from one of the biggest players is worrisome.

And yes, all are at the pre-clinical stage until it comes to humans. But release of the result of tests with pigs soon will be more interesting than others pre-clinical results. Since their skin is more similar to humans than rats.

somehow I do not see the results from the pig trials this year, they have delays, they developed a skin model and it is not clear whether they have already used it or not, never mind that they have money is developing, it all looks better than Tsuji and organ technologies

 

[trialAcc]

Haha, everyone who has hair loss genes are afraid to go bald to the point that the only possible solution is hair cloning.
I'm still young, current at NW3 and stabelized. But I (and I think many other users) really want hair clone to be available in the case that the actual market solutions are not enough to hold a good hair in the future.

Then any less-than-optimistic post from one of the biggest players is worrisome.

And yes, all are at the pre-clinical stage until it comes to humans. But release of the result of tests with pigs soon will be more interesting than others pre-clinical results. Since their skin is more similar to humans than rats.

The only possible solution is not cloning. Your follicles don't die, they can be brought back even if fully miniaturized so long as it hasn't been a decade or two since they went fully silent and fibrosis hasn't start to set in. A good example of this is MtF trans who get semi-full recoveries.

Cloning should be a back up to be honest, because I think the pathways required to restore a lot of our hair will be trialed quicker then the 5-8 years we're looking at here. Good example of that is BAY (other thread here). BAY could be released in 3-4 years and bring back significant hair to the point where you'd only need cloning to probably reshape that perfect hairline. In the monkeys they trialed it on, it brought back fully "bald" areas to 50-70% of normal density in just 6 months. It's possible it could have gone to 100% but they only did the 6 months of dosing.

 

[DuncanOP]

The only possible solution is not cloning. Your follicles don't die, they can be brought back even if fully miniaturized so long as it hasn't been a decade or two since they went fully silent and fibrosis hasn't start to set in. A good example of this is MtF trans who get semi-full recoveries.

Cloning should be a back up to be honest, because I think the pathways required to restore a lot of our hair will be trialed quicker then the 5-8 years we're looking at here. Good example of that is BAY (other thread here). BAY could be released in 3-4 years and bring back significant hair to the point where you'd only need cloning to probably reshape that perfect hairline. In the monkeys they trialed it on, it brought back fully "bald" areas to 50-70% of normal density in just 6 months. It's possible it could have gone to 100% but they only did the 6 months of dosing.

Thanks. I'll read the thread later to know what is it.

I typically don't read threads not related to hair clone or Ant DHTs + AR degraders/blockers haha

 

[Shush]

Then what would you need cloning for? Get your 2k grafts from your dono and god bless

The only possible solution is not cloning. Your follicles don't die, they can be brought back even if fully miniaturized so long as it hasn't been a decade or two since they went fully silent and fibrosis hasn't start to set in. A good example of this is MtF trans who get semi-full recoveries.

Cloning should be a back up to be honest, because I think the pathways required to restore a lot of our hair will be trialed quicker then the 5-8 years we're looking at here. Good example of that is BAY (other thread here). BAY could be released in 3-4 years and bring back significant hair to the point where you'd only need cloning to probably reshape that perfect hairline. In the monkeys they trialed it on, it brought back fully "bald" areas to 50-70% of normal density in just 6 months. It's possible it could have gone to 100% but they only did the 6 months of dosing.

 

[eeyore]

“We don’t know when exactly we’ll get into human clinical trials, but we’ve got a couple of years in front of us to really try to complete the R&D to the point where we have confidence and we’ll just have to see how we progress along that timeline,” Hamilton said. The preclinical work is currently being done in animal models that “can very closely approximate the human skin structure and environment,” the CEO said.”

Where is that quote from? I couldn't find it in their two recent updates.

 

[trialAcc]

Where is that quote from? I couldn't find it in their two recent updates.

It's an interview with a biotech publication on google. Just check the most recent news tab.

I still think they start human trials in 2022.

 

[eeyore]

It's an interview with a biotech publication on google. Just check the most recent news tab.

I still think they start human trials in 2022.

Doesn't his statement kind of imply that they're quite a bit further from human trials than one year?