http://www.sciencedirect.com/science/article/pii/S0738081X07001903
http://www.burnsjournal.com/article/S0305-4179(09)00566-X/abstract
"If you don't bleed, you won't get the results and that is the part that most people aren't willing to do!" pointed out
Dr Desmond Fernandes, who has written numerous papers for medical publications on various plastic surgery procedures, methods of improved penetration and skin needling for collagen stimulation. Naturally, when the blood vessel is pricked, it causes bleeding and this releases the platelet cells inside the blood that carry a mechanism to clot up blood vessels. At the same time, it carries out a lot of growth factors.
http://www.mtsroller.com/timeless-skin/
"When you injure skin tissue, the platelets release growth factors for the skin to heal. It promotes more collagen and elastin. We found that Transforming growth factor beta-3 molecule helps tissue to regenerate instead of scar. When you needle skin, there is a surge of TGFB3. Normally, if we cut the skin, the TGFB3 lasts 24 hours, but when you needle skin there is a surge for two weeks." he said.
The guy is a pioneer of the derma rolling business and one of the top plastic surgeon.
http://www.drdes.co.za/
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[FONT=&]When you (for example) prick your skin you mechanically damage some skin cells. Those cells are too damaged to function properly and our body will immediately start removing those cells.It is the job of our immune system to remove pathogens, damaged cells etc.The capillaries will dilate and the whole area will get red from increased blood flow full of white blood cells and other cells that will be very busy, removing the damaged tissue and the growth of new cells will be triggered. Blood proteins will flood the area and that will cause swelling, the skin will get warmer than normal and will be painful.
Inflammation is a sign that wound healing is in progress.Inflammation is caused by our own immune system. If our immune system didn't "flood" the area and didn't cause inflammation, our wounds would not heal.When you roll your skin, you induce inflammation (which is an immune protective response in order to fix the injury) but you should not get infection (bacterial or other contamination of the wound).[/FONT] [FONT=&]Acute inflammation ceases when the acute injury is fixed and the damaged cells are removed. It takes a few hours (after dermarolling) and up to a few days (after deep single needling) but of course it depends on how deep and dense your pricks are etc. Basically, when the signs of inflammation (redness, swelling, increased heat, pain) are completely gone then the inflammation process is completed.It doesn't mean though that you should roll immediately when the inflammation from the previous rolling is gone. For reasons that are very complex, it is undesirable to have a more or less continuous state of inflammation of the skin. It is certainly not beneficial to your skin.You have to give your skin time to completely regenerate and give your skin time to complete several stages of collagen production (from collagen III to collagen I etc). The tissue remodelling can take months
[/FONT]The advantage of dermarolling compared to those other methods is that it doesn’t remove the outermost layer of skin and there is no danger of burns and other thermal damage.Wound healing has 3 stages -
Inflammation, proliferation and remodeling.Inflammation is a reaction of our body to heal the injury.During the inflammation stage, the blood vessels dilate, resulting in an increased blood flow to the area. The area becomes red and warm. Plasma fluids will flood the area and cause swelling. When the immune system cleans the area of damaged cells, the damaged cells will be replaced by new ones.
The skin consists of 3 layers. The epidermis, the dermis and subdermis.The epidermis has no blood supply. The dermis has irregular blood vessels and the deeper the dermis the more blood vessels. If you puncture a blood vessel you end up with pinpoint bleeding or even bruises.The more damage in the dermis you cause, the more remodeling you will get. For home use, it is much safer to do several rolling sessions with occasional pinpoint bleeding than one "totally bloody" to obtain the same results. Especially if you roll large areas.If your achieve inflammation (your skin temporarily becoming red after dermarolling), the process of skin renewal has been triggered. That is all you need and you have to regularly repeat it to get results. Your expectations must be realistic. Currently there is no method to completely remove scars, stretch marks, significantly change the pore size or texture of your skin or stop the aging process. A lot of it is determined by hereditary factors. You can achieve improvements though.
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http://www.ncbi.nlm.nih.gov/pubmed/23960389
A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study.
Dhurat R,
Sukesh M,
Avhad G,
Dandale A,
Pal A,
Pund P.
Source
Department of Dermatology, L.T.M. Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
Abstract
INTRODUCTION:
Dermal papilla (DP) is the site of expression of various hair growth related genes. Various researches have demonstrated the underlying importance of Wnt proteins and wound growth factors in stimulating DP associated stem cells. Microneedling works by stimulation of stem cells and inducing activation of growth factors.
MATERIALS AND METHODS:
Hundred cases of mild to moderate (III vertex or IV) androgenetic alopecia (Androgenetic Alopecia) were recruited into 2 groups. After randomization one group was offered weekly microneedling treatment with twice daily 5% minoxidil lotion (Microneedling group); other group was given only 5% minoxidil lotion. After baseline global photographs, the scalp were shaved off to ensure equal length of hair shaft in all. Hair count was done in 1 cm(2) targeted fixed area (marked with tattoo) at baseline and at end of therapy (week 12). The 3 primary efficacy parameters assessed were: Change from baseline hair count at 12 weeks, patient assessment of hair growth at 12 weeks, and investigator assessment of hair growth at 12 weeks. A blinded investigators evaluated global photographic response. The response was assessed by 7- point scale.
RESULTS:
(1) Hair counts - The mean change in hair count at week 12 was significantly greater for the Microneedling group compared to the Minoxidil group (91.4 vs 22.2 respectively). (2) Investigator evaluation - Forty patients in Microneedling group had +2 to +3 response on 7-point visual analogue scale, while none showed the same response in the Minoxidil group. (3) Patient evaluation - In the Microneedling group, 41 (82%) patients reported more than 50% improvement versus only 2 (4.5%) patients in the Minoxidil group. Unsatisfied patients to conventional therapy for Androgenetic Alopecia got good response with Microneedling treatment.
CONCLUSION:
Dermaroller along with Minoxidil treated group was statistically superior to Minoxidil treated group in promoting hair growth in men with Androgenetic Alopecia for all 3 primary efficacy measures of hair growth. Microneedling is a safe and a promising tool in hair stimulation and also is useful to treat hair loss refractory to Minoxidil therapy.
any experience?
