Yeah but as the dosage increased efficacy decreased, which already showed that it was a bad product during trials
Published in Nature: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia
- Thread starter Ralph Wiggum
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Were SM's results published in Nature, or another one of the world's most-read and most prestigious academic journals?
Having Nature's network peer-reviewing the study is, to me, the only credible bit here. Everything else appears a little shady, I agree.
Wait and see.
It's published in Nature Scientific Reports, not in Nature. Big difference
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Aw hell, I didn't realize that.
"Critics, such as Derek Lowe, argue that Scientific Reports has a tendency to publish junk science, and have questioned the review process."
www.science.org
"Critics, such as Derek Lowe, argue that Scientific Reports has a tendency to publish junk science, and have questioned the review process."
Science | AAAS
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It was published in the leading dermatology journal.
I don't see much improvement in the photos, and they are probably the best photos in the studio.
I also don't like that they want to certify it as cosmetic. Search "alopecia cosmetic" in google, and you will see thousands of cosmetics, and all of them claim to stop hair loss and increase regeneration by X %. All lies.
But on the other hand, I doubt that an RNA technique can be classified as cosmetic.
I also don't like that they want to certify it as cosmetic. Search "alopecia cosmetic" in google, and you will see thousands of cosmetics, and all of them claim to stop hair loss and increase regeneration by X %. All lies.
But on the other hand, I doubt that an RNA technique can be classified as cosmetic.
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Anti-androgens shouldn't be expected to give much regrowth, only maintenance. The company itself says the product is 83% as efficacious as finasteride; for comparison, do you expect to see huge regrowth with finasteride in the same time-span they tested? No... only maintenance with a little bit of thickening.
Aw hell, I didn't realize that.
"Critics, such as Derek Lowe, argue that Scientific Reports has a tendency to publish junk science, and have questioned the review process."
Science | AAAS
Didnt knew that. If the review process is different and less strict the perception of legitimacy changes. At least for me.
was it not 80% effect of fina at 24 month mark? That is haf the time of fina .. So who know maybe at 48 months it is better than fina at 48 months ..
Huh? No one officially trialed finasteride for 48 months, did they? Either way it's not going to be a linear improvement.
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on the other hand its really easy to become the global lead in such a pathetic underserved market
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Do we know anything about their plan for the US?
I do not see any improvement from the before pics to the after pics. I don't understand why there's any excitement for this product. I can't even say it looks scammy since the before-after pics show no improvement, which means they aren't trying to trick us with doctored pics. Why does anyone care about this ineffective product?
Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia - Scientific Reports
Androgenetic alopecia (Androgenetic Alopecia) is the most common type of hair loss in men and women. Dihydrotestosterone (DHT) and androgen receptor (AR) levels are increased in patients with Androgenetic Alopecia, and DHT-AR signaling correlates strongly with Androgenetic Alopecia pathogenesis. In this study, treatment with self-assembled micelle...www.nature.com
In the high-dose (5 mg/ml) clinical study, AR68 was given once per week for 24 weeks and showed 83% efficacy in increasing hair counts compared with finasteride. No side effects were observed. Therefore, SAMiRNA targeting AR mRNA is a potential novel topical treatment for Androgenetic Alopecia.
I don't see any regrowth either. ZERO. I don't understand why people have any interest in this product.
Exactly, just like KX-826. All the upcoming treatments are just potential alternatives to finasteride/dutasteride. In over 25+ years we still haven't got a new growth stimulant that could replace minoxidil which unfortunately only works for 30-40% of people.
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Tbh maintaining + transplant is a cure for low Norwoods
Ok, but can you really tell if it maintains the hair you have in a 24-week study? Maybe. I'm sure they did hair counts and stuff like that. OK, I might be interested in it as a maintenance treatment.
All except HMI-115